enzymology Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

, a diacylglycerol cholinephosphotransferase () is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

that

catalyzes Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recyc ...

the

chemical reaction A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...

Diacylglycerol cholinephosphotransferase

CDP-choline + 1,2-diacylglycerol

\rightleftharpoons

CMP + a phosphatidylcholine

Thus, the two substrates of this enzyme are

CDP-choline Citicoline (International Nonproprietary Name, INN), also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in ...

and 1,2-diacylglycerol, whereas its two

products Product may refer to: Business * Product (business), an item that serves as a solution to a specific consumer problem. * Product (project management), a deliverable or set of deliverables that contribute to a business solution Mathematics * Produ ...

are CMP and

phosphatidylcholine Phosphatidylcholines (PC) are a class of phospholipids that incorporate choline as a headgroup. They are a major component of biological membranes and can be easily obtained from a variety of readily available sources, such as egg yolk or soyb ...

Classification

This enzyme belongs to the family of

transferase A transferase is any one of a class of enzymes that catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor). They are involved in hundreds of di ...

s, specifically those transferring non-standard substituted phosphate groups.

Nomenclature

The

systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivial ...

of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include: * 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase, * 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase, * 1-alkyl-2-acetylglycerol cholinephosphotransferase, * alkylacylglycerol choline phosphotransferase, * alkylacylglycerol cholinephosphotransferase, * CDP-choline diglyceride phosphotransferase, * cholinephosphotransferase, * CPT, * cytidine diphosphocholine glyceride transferase, * cytidine diphosphorylcholine diglyceride transferase, * diacylglycerol choline phosphotransferase, * phosphocholine diacylglyceroltransferase, * phosphorylcholine-glyceride transferase, and * sn-1,2-diacylglycerol cholinephosphotransferase.

Biological role

This enzyme participates in 3

metabolic pathways In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an enzymatic reaction are known as metabolites, which are modified by a sequence of chemical reac ...

aminophosphonate metabolism Aminophosphonates are organophosphorus compounds with the formula (RO)2P(O)CR'2NR"2. These compounds are structural analogues of amino acids in which a carboxylic moiety is replaced by phosphonic acid or related groups. Acting as antagonists of a ...

glycerophospholipid metabolism Glycerophospholipids or phosphoglycerides are glycerol-based phospholipids. They are the main component of biological membranes. Two major classes are known: those for bacteria and eukaryotes and a separate family for archaea. Structures T ...

, and

ether lipid metabolism In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again be c ...

References

* * * EC 2.7.8 Enzymes of unknown structure {{2.7-enzyme-stub