Zephyr Surgical Implants (ZSI) is a Swiss-based

medical device A medical device is any device intended to be used for medical purposes. Significant potential for hazards are inherent when using a device for medical purposes and thus medical devices must be proved safe and effective with reasonable assura ...

manufacturer that produces and distributes

artificial urinary sphincter An artificial urinary sphincter (AUS) is an implanted device to treat moderate to severe stress urinary incontinence, most commonly in men. The AUS is designed to supplement the function of the natural urinary sphincter that restricts urine flo ...

s and

penile implant A penile implant is an implanted device intended for the treatment of erectile dysfunction, Peyronie's disease, ischemic priapism, deformity and any traumatic injury of the penis, and for phalloplasty or metoidioplasty, including in gender-affi ...

s worldwide. ZSI products are used in the management of moderate-to-severe

urinary incontinence Urinary incontinence (UI), also known as involuntary urination, is any uncontrolled leakage of urine. It is a common and distressing problem, which may have a large impact on quality of life. It has been identified as an important issue in geria ...

in men,

erectile dysfunction Erectile dysfunction (ED), also called impotence, is the type of sexual dysfunction in which the penis fails to become or stay erect during sexual activity. It is the most common sexual problem in men.Cunningham GR, Rosen RC. Overview of male ...

Peyronie's disease Peyronie's disease is a connective tissue disorder involving the growth of fibrous plaques in the soft tissue of the penis. Specifically, scar tissue forms in the tunica albuginea, the thick sheath of tissue surrounding the corpora cavernosa, ca ...

penis enlargement Penis enlargement, or male enhancement, is any technique aimed to increase the size of a human penis. Some methods aim to increase total length, others the shaft's girth, and yet others the glans size. Techniques include surgery, supplements, o ...

, and

female-to-male A trans man is a man who was assigned female at birth. The label of transgender man is not always interchangeable with that of transsexual man, although the two labels are often used in this way. ''Transgender'' is an umbrella term that incl ...

gender reassignment surgery Gender-affirming surgery (GAS) is a surgical procedure, or series of procedures, that alters a transgender or transsexual person's physical appearance and sexual characteristics to resemble those associated with their identified gender, and alle ...

History

The company was founded by Dr. Christophe Llorens and Raphael Llorens in 2005. The first product – ZSI 375

, was introduced in 2009. As of 2019, more than 4500 ZSI 375 artificial urinary sphincters were implanted worldwide. The inflatable penile implant designed for female-to-male gender assignment surgeries became available in the European market in March 2016, and the first

phalloplasty Phalloplasty is the construction or reconstruction of a penis or the artificial modification of the penis by surgery. The term is also occasionally used to refer to penis enlargement. History Russian surgeon Nikolaj Bogoraz performed the firs ...

procedures using ZSI 475 FtM implants were performed in June 2016. Many clinical studies have been performed with the artificial urinary sphincter ZSI 375 in the treatment of moderate and severe stress incontinence, most of them are retrospective and non-randomized tests. Success rates in total or social continence vary, in a period of 6 to 24 months, between 68-89%.

References

{{Reflist Medical technology companies of Switzerland Companies of Switzerland Health care companies established in 2005 Companies based in Geneva Manufacturing companies based in Geneva Swiss brands Medical device manufacturers Swiss companies established in 2005