Zenarestat (FK-366; FR-74366) is an

aldose reductase inhibitor Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Mechanism Their target, aldose reductase, is an enzyme that is normally present in many other parts of the body, and ...

. It was investigated as a treatment of

diabetic neuropathy Diabetic neuropathy is various types of nerve damage associated with diabetes mellitus. Symptoms depend on the site of nerve damage and can include motor changes such as weakness; sensory symptoms such as numbness, tingling, or pain; or autonomic c ...

and

cataract A cataract is a cloudy area in the lens of the eye that leads to a decrease in vision. Cataracts often develop slowly and can affect one or both eyes. Symptoms may include faded colors, blurry or double vision, halos around light, trouble w ...

, but its development was terminated.

References

* M. Hashimoto et al., EP 218999; eidem, US 4734419 (1987, 1988 both to Fujisawa) * Inhibition kinetics and effect on sorbitol accumulation: S. Ao et al., Metabolism 40, 77 (1991) * Pharmacokinetics and metabolism in diabetic rats: Y. Tanaka et al., Drug Metab. Dispos. 21, 677 (1993) * M. Kanamaru et al., J. Clin. Pharmacol. 33, 1122 (1993). Abandoned drugs Aldose reductase inhibitors Orphan drugs {{gastrointestinal-drug-stub