Zambon
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Zambon is an Italian company that has been operating in the
pharmaceutical A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...
and fine chemical industry since 1906. The company is currently run by Elena Zambon who is the daughter of the founder.{{Cite news, url=http://www.repubblica.it/economia/affari-e-finanza/2017/07/03/news/credito_e_industria_il_nord-est_volta_pagina_i_nuovi_signori_della_locomotiva_italiana-169825826/?refresh_ce, title=Credito e industria, il Nord-Est volta pagina: i nuovi signori della locomotiva italiana, date=2017-07-03, work=Repubblica.it, access-date=2018-08-08, language=it Headquartered in
Bresso Bresso (Milanese: ) is a ''comune'' (municipality) in the Metropolitan City of Milan in the Italian region Lombardy, located about north of Milan. At the 2001 census the municipality had a population of 26,255 inhabitants and a population densit ...
, in the
Province of Milan The Province of Milan ( it, Provincia di Milano) was a province in the Lombardy region, Italy. Its capital was the city of Milan. The area of the former province is highly urbanized, with more than 2,000 inhabitants/km2, the third highest populati ...
, the company has business operations in three continents: Europe, South America and Asia. The company employs approximately 2,600 people in 15 countries and its integrated organisation consists of Zambon Company SpA, the industrial holding company for the group which comprises Zach System (
fine chemical In chemistry, fine chemicals are complex, single, pure chemical substances, produced in limited quantities in multipurpose plants by multistep batch chemical or biotechnological processes. They are described by exacting specifications, used f ...
s), Zambon SpA (
pharmaceutical A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the medical field and re ...
s) and Z-Cube (Research Venture).


History


Origins

Gaetano Zambon, founder of the group, was born in
Malo Mal, which in Spanish means ''bad or evil'', may also refer to: Places * Malo, Italy, a town *Malo Island, formerly known as St. Bartholomew, Vanuatu * Malo (Solomon Islands), an island *Malo, Washington, Ferry County, Washington, United States * ...
in the
Province of Vicenza The Province of Vicenza ( it, Provincia di Vicenza) is a province in the Veneto region in northern Italy. Its capital city is Vicenza. The province has an area of 2,722.53 km², and a total population of 865,082 (as of 2017). There are 1 ...
on 31 December 1878. His father Giovanni owned a corn business. Gaetano Zambon studied pharmacy at the University of Padua and graduated in 1902. Seeing the potential and growth of the pharmaceutical sector, he decided to sell products directly to pharmacies. Partnering with Silvio Farina, the two bought out the Rossi medical products warehouse on Corso Fogazzaro in Vicenza in August 1906 and officially founded the Magazzino Medicinali Zambon (Zambon Medical Products Warehouse) on 11 November 1906.


Establishment

The Warehouse distributed basic pharmaceutical products such as
bismuth Bismuth is a chemical element with the Symbol (chemistry), symbol Bi and atomic number 83. It is a post-transition metal and one of the pnictogens, with chemical properties resembling its lighter group 15 siblings arsenic and antimony. Elemental ...
,
iodine Iodine is a chemical element with the symbol I and atomic number 53. The heaviest of the stable halogens, it exists as a semi-lustrous, non-metallic solid at standard conditions that melts to form a deep violet liquid at , and boils to a vi ...
and
bicarbonate In inorganic chemistry, bicarbonate (IUPAC-recommended nomenclature: hydrogencarbonate) is an intermediate form in the deprotonation of carbonic acid. It is a polyatomic anion with the chemical formula . Bicarbonate serves a crucial biochemic ...
, and also other commodities such as
liquorice Liquorice (British English) or licorice (American English) ( ; also ) is the common name of ''Glycyrrhiza glabra'', a flowering plant of the bean family Fabaceae, from the root of which a sweet, aromatic flavouring can be extracted. The liqu ...
, spices and
talcum powder Talc, or talcum, is a clay mineral, composed of hydrated magnesium silicate with the chemical formula Mg3Si4O10(OH)2. Talc in powdered form, often combined with corn starch, is used as baby powder. This mineral is used as a thickening age ...
. In 1908, the two partners established Gaetano Zambon & Co whose shares were divided equally between Gaetano, Silvio Farina and Teodorico Viero. In 1911, the business expanded over the entire region, forcing them to move to new offices.


The First World War

The outbreak of the First World War slowed business but did not halt it altogether. Gaetano Zambon provided services for the Military Medical Corps and during this period, partners Teodorico Viero, Silvio Farina and Arrigo Giacomelli expanded the company to include Giovanni Ferrari who also had a background in pharmaceuticals and sales.


The post-war period and establishment of ZeF

G. Zambon & Co. had a small plant that produced products for chemists such as Elixir di China (Elixir of
Quinine Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to ''Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg cr ...
), Ferrochina (iron and quinine citrate bitters), Rheum (
rhubarb Rhubarb is the fleshy, edible stalks ( petioles) of species and hybrids (culinary rhubarb) of ''Rheum'' in the family Polygonaceae, which are cooked and used for food. The whole plant – a herbaceous perennial growing from short, thick rhizo ...
) and an
insecticide Insecticides are substances used to kill insects. They include ovicides and larvicides used against insect eggs and larvae, respectively. Insecticides are used in agriculture, medicine, industry and by consumers. Insecticides are claimed to b ...
called ITE. In 1920, Gaetano Zambon and his partners established their product lines, founding the first laboratory for speciality products and
Galenic formulation Galenic formulation deals with the principles of preparing and compounding medicines in order to optimize their absorption. Galenic formulation is named after Claudius Galen, a 2nd Century AD Greek physician, who codified the preparation of drugs ...
s, under the brand name ZeF (Zambon and Farina), for distribution to pharmacies and hospitals. In 1930, they bought an old fertiliser plant which was to become the company’s new pharmaceutical production facility. The first Synthetic Product Department was established in 1933, completing the pharmaceutical production process from raw material to finished product.


Zambon & Co. And the Second World War

In 1937, Gaetano Zambon and Silvio Farina were appointed Knights of the Order of the Crown of Italy and in 1938, after the departure of Teodorico from the company, they formed Zambon & C. Società Anonima per Azioni (Zambon & Co. Join Stock Company), and increasing the number of employees from 100 to 300 within a decade. During the Second World War, the factory suffered heavy bombing on 14 May 1944 and much of it was destroyed. The new Zambon plant was opened in September 1946, with the Minister of Foreign Trade, Pietro Campilli in attendance. Pharmaceuticals produced by Zambon were also sold abroad. After the Second World War, the first generation of Zambon partners decided to hand over the reins to the younger generation. After parting ways with the Farina branch in 1951 and the Ferraris in 1957, Alberto Zambon took over the management of the company. Gaetano Zambon died in 1959 at the age of 81 years, and the company changed its name once more to Zambon SpA. Alberto Zambon established good relationships in the United States and with a few large multinationals existing at that time, especially in the field of research, so that the company could develop its own pharmaceuticals rather than licensing them.


Internationalisation

The company expanded abroad, setting up both production facilities and commercial operations. They opened the first production plant in Brazil in 1956 under the name Zambon Laboratorios Farmaceuticos SA, which was changed to Ltda in 1993. Zambon SA was established in Barcelona, Spain, in 1960 to serve the Iberian Peninsula (an independent Portuguese headquarters was opened in
Lisbon Lisbon (; pt, Lisboa ) is the capital and largest city of Portugal, with an estimated population of 544,851 within its administrative limits in an area of 100.05 km2. Grande Lisboa, Lisbon's urban area extends beyond the city's administr ...
, in 1992). The main brand of Zambon on the Spanish market is
Ultra Levura adopted by British military intelligence in June 1941 for wartime signals intelligence obtained by breaking high-level encrypted enemy radio and teleprinter communications at the Government Code and Cypher School (GC&CS) at Bletchley Park. ' ...
, a probiotic treatment. In 1961, Alberto Zambon moved the main headquarters and research laboratories to Bresso, Milan, while the production facility remained in Vicenza. In 1963, Inpharzam was founded in Lamone, Switzerland, which served as a holding group for all the international businesses. This branch later moved to
Cadempino Cadempino is a municipality in the district of Lugano in the canton of Ticino in Switzerland. History Cadempino is first mentioned in 1004 as ''Cadampinus''. Originally, it was owned by the Totoniden family of Campione d'Italia. In 844 their ...
, where a specialist pharmaceutical production plant was established. Davizam SA, Siphar and the Inpharzam Trading Company SA were also established in
Lugano Lugano (, , ; lmo, label=Ticinese dialect, Ticinese, Lugan ) is a city and municipality in Switzerland, part of the Lugano District in the canton of Ticino. It is the largest city of both Ticino and the Italian-speaking southern Switzerland. Luga ...
. Founded in the same year, Zambon France focused on sales and exports to Africa and Australia. Fluimicil went on the market in 1965. During this period, the company started to build relationships in Japan through a collaboration with EISAI, which produced injectable
chloramphenicol Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, a ...
in Japan. A new chemical ingredients plant was built in Almisano di Lonigo in 1970. In 1975, Zambon Colombia SA was established with headquarters in Bogota. In 1980, Inpharzam International established relationships with various companies, including Carlo Erba. In 1983, Zambon bought out Emilio Ghirardi’s company Simes and production was moved to a new plant in Vicenza in 1984. That same year, Zambon B.V. was founded with headquarters in Amsterdam and Zambon Nederland BV was established. A year later, Alberto Zambon was appointed a Knight of the Order of Merit for Labour, exactly 50 years after his father’s nomination. 1989 saw the founding of both Zambon UK and Zambon Corporation for the American market. In 1996, the Shantou Shanning Zambon Chemicals Ltd (Equity Joint Venture) was founded and its plant was opened a year later. In Europe, Inpharzam SA was established in Belgium in 1995. In 2000, a second Chinese plant was opened in Hainan, dividing chemical and pharmaceutical production between Shantou and Hainan. In 2002 Zambon India was established and Zambon Indonesia two years later. The group invested in the respiratory field, especially in the treatment of severe diseases such as
chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) is a type of progressive lung disease characterized by long-term respiratory symptoms and airflow limitation. The main symptoms include shortness of breath and a cough, which may or may not produce ...
and rare illnesses, and in June 2013, Zambon acquired Profile Pharma in the United Kingdom, which specialised in
cystic fibrosis Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. O ...
. At the same time, Zambon entered the central nervous system therapy area with the molecule
safinamide Safinamide (INN; brand name Xadago) is a drug used as an add-on treatment for Parkinson's disease with "off" episodes; it has multiple modes of action, including the inhibition of monoamine oxidase B. SeFDA index page for NDA 207145for updates ...
.


Branches

* Italy * Switzerland * France * Belgium * England * Germany * Netherlands * Spain * Portugal * Russia * Brazil * Colombia * China * India (in collaboration with ModiMundi Pharma Pvt Ltd) * Indonesia


References

Italian companies established in 1906 Pharmaceutical companies of Italy Pharmaceutical companies established in 1906 Multinational companies headquartered in Italy