Zinc finger protein 57 homolog (ZFP57), also known as zinc finger protein 698 (ZNF698), is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''ZFP57''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is a
zinc finger
A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn2+) in order to stabilize the fold. It was originally coined to describe the finger-like appearance of a hypothesized struct ...
protein containing a
KRAB domain
KRAB (106.1 FM broadcasting, FM, "Alt 106.1") is a commercial alternative rock music radio station in Greenacres, California, broadcasting to the Bakersfield, California, area. The station is owned by iHeartMedia, Inc. Its studios are located ...
. Studies in mouse suggest that this protein may function as a transcriptional
repressor.
Clinical significance
Mutations in the ZFP57 gene may be associated with
transient neonatal diabetes mellitus.
References
Further reading
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