The yybP-ykoY leader RNA element was originally discovered in ''

E. coli ''Escherichia coli'' (),Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. also known as ''E. coli'' (), is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escher ...

'' during a large scale screen and was named SraF. This family was later found to exist

upstream Upstream may refer to: * Upstream (bioprocess) * ''Upstream'' (film), a 1927 film by John Ford * Upstream (networking) * ''Upstream'' (newspaper), a newspaper covering the oil and gas industry * Upstream (petroleum industry) * Upstream (software ...

of related families of protein genes in many bacteria, including the yybP and ykoY genes in ''

B. subtilis ''Bacillus subtilis'', known also as the hay bacillus or grass bacillus, is a Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants, humans and marine sponges. As a member of the genus ''Bacillus' ...

''. The specific functions of these proteins are unknown, but this structured RNA element may be involved in their genetic regulation as a riboswitch. The ''yybP-ykoY'' element was later proposed to be manganese-responsive after another associated family of genes, ''YebN/MntP'', was shown to encode Mn²⁺ efflux pumps in several bacteria. Genetic data and a crystal structure confirmed that ''yybp-ykoY'' is a manganese riboswitch that directly binds Mn²⁺

References

External links

* Cis-regulatory RNA elements {{molecular-cell-biology-stub