"You Don't Want to Know" is the eighth episode of the fourth season of the American TV drama ''

House A house is a single-unit residential building. It may range in complexity from a rudimentary hut to a complex structure of wood, masonry, concrete or other material, outfitted with plumbing, electrical, and heating, ventilation, and air c ...

'' and the seventy-eighth episode overall. It aired on 20 November 2007. Notably, in this episode the

differential diagnosis In healthcare, a differential diagnosis (DDx) is a method of analysis that distinguishes a particular disease or condition from others that present with similar clinical features. Differential diagnostic procedures are used by clinicians to di ...

is confirmed as

lupus Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common ...

despite the fact that 'It's not lupus - it's ''never'' lupus' is a phrase often used to the point of

catchphrase A catchphrase (alternatively spelled catch phrase) is a phrase or expression recognized by its repeated utterance. Such phrases often originate in popular culture and in the arts, and typically spread through word of mouth and a variety of mass ...

by the eponymous Dr. Gregory House.

Plot

Flynn, a magician, collapses during a performance and is brought to Princeton-Plainsboro. House and his team initially suspect several conditions, including

tularemia Tularemia, also known as rabbit fever, is an infectious disease caused by the bacterium '' Francisella tularensis''. Symptoms may include fever, skin ulcers, and enlarged lymph nodes. Occasionally, a form that results in pneumonia or a throat ...

and

amyloidosis Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. There are several non-specific and vague signs and symptoms associated with amyloidosis. These include fatigue, peripheral edema, weigh ...

, as Flynn suffers from worsening symptoms such as internal bleeding and seizures. After a failed blood transfusion experiment involving House, they discover Flynn had been given the wrong blood type, leading House to diagnose

autoimmune hemolytic anemia Autoimmune hemolytic anemia (AIHA) occurs when a person's immune system produces antibodies directed against their own red blood cells (RBCs). These antibodies attach to red cells, causing them to break down ( lyse), and reducing the number of ox ...

caused by

systemic lupus erythematosus Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary among people and may be mild to severe. Common ...

. Despite House's famous insistence throughout the series that "It's never lupus," this case turns out to be lupus, marking a rare exception to the series rule. Alongside the medical case, House challenges his fellows to steal

Lisa Cuddy Lisa Cuddy, M.D., is a fictional character on the medical drama ''House''. She is portrayed by Lisa Edelstein. Cuddy was the dean of medicine of the fictional Princeton-Plainsboro Teaching Hospital in New Jersey. Cuddy quit her job after the event ...

’s underwear in a contest. Cole wins, but House fires him for breaking the rules by involving Cuddy in the scheme, as the contest was intended to test their ability to outwit her without getting caught. Thirteen also deals with her fear of having Huntington's disease, ultimately choosing not to know the results of a genetic test House secretly conducted.

References

External links

"You Don't Want to Know"
at Fox.com * {{House (TV series) House season 4 episodes 2007 American television episodes Television episodes directed by Lesli Linka Glatter fr:Les Dessous des cartes