Yfr1 is a Cyanobacterial
functional RNA that was identified by a
comparative genome based screen for
RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...
s in
cyanobacteria
Cyanobacteria (), also known as Cyanophyta, are a phylum of gram-negative bacteria that obtain energy via photosynthesis. The name ''cyanobacteria'' refers to their color (), which similarly forms the basis of cyanobacteria's common name, blu ...
.
Further analysis has shown that the RNA is well conserved and highly
expressed in cyanobacteria.
and is required for growth under several stress condition
Bioinformatics
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...
research combined with follow-up experiments have shown that Yfr1 inhibits the translation of the proteins PMM1119 and PMM1121 by an antisense interaction by base pairing at the
ribosomal binding site A ribosome binding site, or ribosomal binding site (RBS), is a sequence of nucleotides upstream of the start codon of an mRNA transcript that is responsible for the recruitment of a ribosome during the initiation of translation. Mostly, RBS refers ...
.
See also
*
Yfr2 RNA
*
Cyano-S1 RNA motif
*
Cyano-2 RNA motif
The Cyano-2 RNA motif is a conserved RNA structure identified by bioinformatics. Cyano-2 RNAs are found in Cyanobacterial species classified within the genus ''Synechococcus''. Many terminal loops in the two conserved stem-loops contain the nuc ...
References
External links
*
Non-coding RNA
Antisense RNA
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