William Silverman
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William Aaron Silverman (October 23, 1917 – December 16, 2004) was an American physician who made important contributions to
neonatology Neonatology is a subspecialty of pediatrics that consists of the medical care of newborn infants, especially the ill or premature newborn. It is a hospital-based specialty, and is usually practised in neonatal intensive care units (NICUs). The ...
. He held academic positions at Columbia University College of Physicians and Surgeons and served as the medical director of the neonatal intensive care unit at Columbia-Presbyterian Medical Center. Silverman urged physicians to address considerations like quality of care in formulating medical treatment plans, especially in the management of premature infants.


Biography


Early life

Silverman was born in Cleveland in 1917. In an interview late in his life, Silverman said that his mother had
rheumatic heart disease Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The disease typically develops two to four weeks after a streptococcal throat infection. Signs and symptoms include fever, multiple painful jo ...
and that she struggled with her health after he was born, so he was raised mostly by his grandparents. Silverman was also sickly as a child. His family moved to Los Angeles in 1920, hoping that the climate would have beneficial effects on the health of Silverman and his mother. Silverman's mother died of a stroke two years later. He completed undergraduate studies at the
University of California, Los Angeles The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California St ...
(UCLA). Silverman earned a medical degree from the
University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...
(UCSF). He completed a residency at Columbia-Presbyterian Medical Center.


Appointments and service

Remaining on the staff at Columbia-Presbyterian after his residency, Silverman later became the director of the hospital's
neonatal intensive care unit A neonatal intensive care unit (NICU), also known as an intensive care nursery (ICN), is an intensive care unit (ICU) specializing in the care of ill or premature newborn infants. Neonatal refers to the first 28 days of life. Neonatal care, as kn ...
. After many years at Columbia-Presbyterian, Silverman moved back to California and directed the neonatal intensive care unit at San Francisco Children's Hospital. He also spent time working with children who had been blinded by
retinopathy of prematurity Retinopathy of prematurity (ROP), also called retrolental fibroplasia (RLF) and Terry syndrome, is a disease of the eye affecting prematurely born babies generally having received neonatal intensive care, in which oxygen therapy is used due to ...
, previously known as retrolental fibroplasia.


Contributions

In the 1950s, Silverman contributed to the knowledge that retinopathy of prematurity was related to the high concentrations of oxygen administered to premature infants. Early in his career, he had conducted a trial that examined the use of adrenocorticotropic hormone (ACTH) in treating retinopathy of prematurity. Though his research seemed to support ACTH as an effective treatment for the condition, researchers at Johns Hopkins University School of Medicine disproved this connection. The experience with ACTH made a strong impression on Silverman, who became adamant that strong scientific evidence must guide medical decisions. Epidemiologist
David Sackett David Lawrence Sackett (November 17, 1934 – May 13, 2015) was an American-Canadian physician and a pioneer in evidence-based medicine. He is known as one of the fathers of Evidence-Based Medicine. He founded the first department of clinical ...
said that Silverman was "clearly the pioneer" in
evidence-based medicine Evidence-based medicine (EBM) is "the conscientious, explicit and judicious use of current best evidence in making decisions about the care of individual patients". The aim of EBM is to integrate the experience of the clinician, the values of t ...
. Emphasizing that physicians must consider
quality of life Quality of life (QOL) is defined by the World Health Organization as "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards ...
before deciding to pursue new and aggressive treatments in the neonatal intensive care unit, Silverman supported the right of parents to decide that their severely premature babies should not be resuscitated. Referring to Silverman's position in medicine in the 1950s, UCSF physician Malcolm Holliday said, "Bill was really regarded as the premier neonatologist of that period."


Later life

In 2003, the American Foundation for the Blind awarded its highest honor, the Migel Medal, to Silverman. He died of
renal failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...
in late 2004. Upon his death, he had been married to Ruth Silverman for 59 years. They had three children.


Legacy

The Cochrane Collaboration awards the Bill Silverman Prize to a researcher who evaluates and improves the presentation, maintenance or dissemination of the collaboration's materials. The
American Academy of Pediatrics The American Academy of Pediatrics (AAP) is an American professional association of pediatricians, headquartered in Itasca, Illinois. It maintains its Department of Federal Affairs office in Washington, D.C. Background The Academy was founded ...
honored him in 2006 with the creation of the William A. Silverman Lectureship.


Selected publications

*''Dunham's Premature Infants, Third Edition'' (1961)


References


External links


William A. Silverman Papers

Silverman and Butterfield Infant Incubator Research Collection
{{DEFAULTSORT:Silverman, William 1917 births 2004 deaths American pediatricians University of California, Los Angeles alumni University of California, San Francisco alumni Columbia Medical School faculty University of California, San Francisco faculty Deaths from kidney failure in California