William Canfield is a glycobiologist, chief scientific officer and founder of an Oklahoma City-based biotechnology company, Novazyme, which was acquired by Genzyme in August 2001 and developed, among other things, an enzyme that can stabilize (but not cure)

Pompe disease Glycogen storage disease type II, also called Pompe disease, is an autosomal recessive metabolic disorder which damages muscle and nerve cells throughout the body. It is caused by an accumulation of glycogen in the lysosome due to deficiency of th ...

, based on Canfield's ongoing research since 1998. Canfield subsequently left Genzyme and established, with his partner in the Novazyme operation,

John Crowley John Crowley may refer to: *John Crowley (Irish revolutionary) (1891-1942), Irish revolutionary and hunger striker *John Crowley (author) (born 1942), American author *John Crowley (baseball) (1862–1896), American Major League catcher *John Crowl ...

, another research laboratory ( Cytovance Biologics), which he still heads. He saved Cytovance from bankruptcy by forming an investor group and raising $9 million after Crowley suddenly left the lab in 2005 to become the chief executive officer at Amicus Therapeutics in New Jersey

Biography

Canfield obtained a B.S. in

Chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

from the

University of Puget Sound The University of Puget Sound (UPS or Puget Sound) is a private university in Tacoma, Washington. The university draws approximately 2,600 students from 44 states and 16 countries. It offers 1,200 courses each year in more than 50 traditional an ...

followed by a Ph.D. in

Biochemistry and Molecular Biology Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology an ...

and an M.D. from the School of Medicine at the University of Washington. Canfield currently holds a faculty position in medical glycobiology at the

University of Oklahoma Health Sciences Center The University of Oklahoma Health Sciences Center is a public medical school in Oklahoma City, Oklahoma. It is the health sciences branch of the University of Oklahoma and serves as the primary place of instruction for many of Oklahoma's health p ...

took over a position as a CEO in Novazyme after leaving Bristol-Myers Squibb in March 2000 and together with Dr. Y. T. Chen at

Duke University Duke University is a private research university in Durham, North Carolina. Founded by Methodists and Quakers in the present-day city of Trinity in 1838, the school moved to Durham in 1892. In 1924, tobacco and electric power industrialist James ...

pushed for expedited approval by the U.S. Food and Drug Administration (FDA) of a new drug compound, NZ-1001 under orphan drug designation for the treatment of Glycogen storage disease type II in October 2005. The FDA stated: “We have determined that Novazyme’s recombinant human highly phosphorylated acid alpha-glucosidase (rhHPGAA) qualifies for orphan designation for enzyme replacement therapy in patients with all subtypes of glycogen storage disease type II (Pompe's disease).” Subsequent research at Genzyme on NZ-1001 along with three other potential compounds brought approval of the first enzyme replacement therapy for Pompe's disease - Alglucosidase alfa (Myozyme or Lumizyme, Genzyme Inc) in 2006.

Popular culture

William Canfield's work with Pompe Disease was fictionalized and made the subject of a 2010 movie '' Extraordinary Measures'' in which he is called Dr. Robert Stonehill and played by

Harrison Ford Harrison Ford (born July 13, 1942) is an American actor. His films have grossed more than $5.4billion in North America and more than $9.3billion worldwide, making him the seventh-highest-grossing actor in North America. He is the recipient o ...

References

{{DEFAULTSORT:Canfield, William Year of birth missing (living people) Living people American medical researchers University of Oklahoma faculty University of Puget Sound alumni University of Washington School of Medicine alumni