Wilhelm Feldberg
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Wilhelm Siegmund Feldberg (19 November 1900 – 23 October 1993) was a German-British
physiologist Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical a ...
and
biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual Cell (biology), cell, a multicellular organism, or a Community (ecology), community of Biological inter ...
.


Biography

Feldberg was born in
Hamburg (male), (female) en, Hamburger(s), Hamburgian(s) , timezone1 = Central (CET) , utc_offset1 = +1 , timezone1_DST = Central (CEST) , utc_offset1_DST = +2 , postal ...
to a wealthy middle class
Jewish family Jews ( he, יְהוּדִים, , ) or Jewish people are an ethnoreligious group and nation originating from the Israelites Israelite origins and kingdom: "The first act in the long drama of Jewish history is the age of the Israelites""Th ...
. He studied
medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...
at
Heidelberg Heidelberg (; Palatine German language, Palatine German: ''Heidlberg'') is a city in the States of Germany, German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. As of the 2016 census, its population was 159,914 ...
,
Munich Munich ( ; german: München ; bar, Minga ) is the capital and most populous city of the States of Germany, German state of Bavaria. With a population of 1,558,395 inhabitants as of 31 July 2020, it is the List of cities in Germany by popu ...
and
Berlin Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...
, graduating in 1925. In the same year he moved with his new wife to England and studied first under
John Newport Langley John Newport Langley (2 November 1852 – 5 November 1925) was a British physiologist, who made substantive discoveries about the nervous system and secretion. Life He was born in Newbury, Berkshire the son of John Langley, the local schoolmast ...
at Cambridge and then Henry Dale at Hampstead. In 1927 he returned to the Physiological Institute in Berlin but he was dismissed in 1933 during the
Nazi Nazism ( ; german: Nazismus), the common name in English for National Socialism (german: Nationalsozialismus, ), is the far-right totalitarian political ideology and practices associated with Adolf Hitler and the Nazi Party (NSDAP) in ...
purge of Jewish scientists. With the aid of
Archibald Hill Archibald Vivian Hill (26 September 1886 – 3 June 1977), known as A. V. Hill, was a British physiologist, one of the founders of the diverse disciplines of biophysics and operations research. He shared the 1922 Nobel Prize in Physiology or M ...
's Academic Assistance Council, Feldberg was relocated to Britain's
National Institute for Medical Research The National Institute for Medical Research (commonly abbreviated to NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR b ...
in 1934–36. Here, he worked with
Henry Hallett Dale Sir Henry Hallett Dale (9 June 1875 – 23 July 1968) was an English pharmacologist and physiologist. For his study of acetylcholine as agent in the chemical transmission of nerve pulses (neurotransmission) he shared the 1936 Nobel Prize in Ph ...
, providing a significant impetus for Dale's
Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
winning research into chemical
neurotransmission Neurotransmission (Latin: ''transmissio'' "passage, crossing" from ''transmittere'' "send, let through") is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), ...
. Feldberg was subsequently offered a place in
Australia Australia, officially the Commonwealth of Australia, is a Sovereign state, sovereign country comprising the mainland of the Australia (continent), Australian continent, the island of Tasmania, and numerous List of islands of Australia, sma ...
, at the behest of
Charles Kellaway Charles Halliley Kellaway, (16 January 1889 – 13 December 1952) was an Australian medical researcher and science administrator. Biography Early years and education Charles Kellaway was born at the parsonage attached to St James's Old Cathe ...
, director of the
Walter and Eliza Hall Institute of Medical Research WEHI (), previously known as the Walter and Eliza Hall Institute of Medical Research, and as the Walter and Eliza Hall Institute, is Australia's oldest medical research institute. Sir Frank Macfarlane Burnet, who won the Nobel Prize in 1960 for ...
. He spent two years (1936–38) in
Melbourne Melbourne ( ; Boonwurrung/Woiwurrung: ''Narrm'' or ''Naarm'') is the capital and most populous city of the Australian state of Victoria, and the second-most populous city in both Australia and Oceania. Its name generally refers to a met ...
, joining Kellaway's
snake venom Snake venom is a highly toxic saliva containing zootoxins that facilitates in the immobilization and digestion of prey. This also provides defense against threats. Snake venom is injected by unique fangs during a bite, whereas some species are a ...
research programme. This work developed into a study of tissue responses to direct and indirect insult, focusing particularly on the liberation of
histamine Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered in ...
and other endogenous mediators. A finding of lasting pharmacological interest from these studies was the identification and partial isolation of the
slow-reacting substance of anaphylaxis The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation. It can be found in basophils. It induces prolonged, slow co ...
. Although Feldberg had earned a fellowship supported by the Australian
National Health and Medical Research Council The National Health and Medical Research Council (NHMRC) is the main statutory authority of the Australian Government responsible for medical research. It was the eighth largest research funding body in the world in 2016, and NHMRC-funded rese ...
, in 1938 he was offered a readership in physiology at
Cambridge University , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...
. He returned to England to take up this post, remaining there throughout
World War II World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposin ...
until 1949. Feldberg's subsequent appointments include: Head of Physiology and Pharmacology Division, National Institute for Medical Research, London, 1949–65 (Honorary Head of Division, 1965–66); Head, Laboratory of Neuropharmacology, National Institute for Medical Research, 1966–74. He was elected a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
in 1947 and made a
Commander of the Order of the British Empire The Most Excellent Order of the British Empire is a British order of chivalry, rewarding contributions to the arts and sciences, work with charitable and welfare organisations, and public service outside the civil service. It was established o ...
in 1963. Wilhelm Feldberg assisted many research workers who came to
England England is a country that is part of the United Kingdom. It shares land borders with Wales to its west and Scotland to its north. The Irish Sea lies northwest and the Celtic Sea to the southwest. It is separated from continental Europe b ...
as a part of their Commonwealth Medical Fellowship and Wellcome Research Fellowship. Under this Fellowships, Professor
PN Saxena Prem Narain Saxena (15 October 1925 – 29 November 1999) was the Founder Professor and Chairman of the Department of Pharmacology, Jawaharlal Nehru Medical College, India. He made several notable contributions to the fields of traditional medi ...
and Prof. KP Gupta of the Department of Pharmacology, Jawaharlal Nehru Medical College,
Aligarh Muslim University Aligarh Muslim University (abbreviated as AMU) is a Public University, public Central University (India), central university in Aligarh, Uttar Pradesh, India, which was originally established by Sir Syed Ahmad Khan as the Muhammadan Anglo-Orie ...
, during the 1970s got many papers published together with Wilhelm Feldberg while their vocation at
National Institute for Medical Research The National Institute for Medical Research (commonly abbreviated to NIMR), was a medical research institute based in Mill Hill, on the outskirts of north London, England. It was funded by the Medical Research Council (MRC); In 2016, the NIMR b ...
,
Mill Hill Mill Hill is a suburb in the London Borough of Barnet, England. It is situated around northwest of Charing Cross. Mill Hill was in the historic county of Middlesex until 1965, when it became part of Greater London. Its population counted 18, ...
.


Controversy

Feldberg's career was ended in 1990 when two
animal rights Animal rights is the philosophy according to which many or all sentient animals have moral worth that is independent of their utility for humans, and that their most basic interests—such as avoiding suffering—should be afforded the sa ...
activists gained access to his lab on the pretence of writing a biography and filming an educational video. Their claims were printed in ''
The Independent ''The Independent'' is a British online newspaper. It was established in 1986 as a national morning printed paper. Nicknamed the ''Indy'', it began as a broadsheet and changed to tabloid format in 2003. The last printed edition was publis ...
''. An investigation by the Medical Research Council found that some breaches of regulations had occurred. While these may not have been Feldberg's fault, he was deemed responsible and his Home Office Project Licence was revoked. One of the animal rights activists involved, Melody MacDonald, detailed her claims in her 1994 book ''Caught in the Act: The Feldberg Investigation'' (). Feldberg became infamous, as MacDonald puts it, for his severe cruelty during animal research experiments. In the year of 1990, an investigation by the animal welfare group
Advocates for Animals OneKind is a campaigning animal welfare charity based in Edinburgh and operating in Scotland, UK and as part of the Eurogroup for Animals Eurogroup for Animals is an animal protection lobby group based in Brussels, Belgium, that seeks to im ...
revealed experiments in which rabbits were regularly burned and operated on without adequate anaesthesia, or even at all, and sometimes even without being covered by a licence. These revelations came when Feldberg was 89 years old. These experiments took place at the National Institute for Medical Research laboratories, Mill Hill, in London, which relate to the functions and decisions of the Home Department. These experiments took place between 1989 and 1990. Along with Feldberg's technician Mr. Stean, the Medical Research Council Inquiry found that he caused both unnecessary suffering to animals. MacDonald reports that Feldberg experimented by pouring various chemicals into the brains of cats while alive and fully conscious. However, as MacDonald and the inquiry found, it was his experiments on rabbits that brought about his downfall and subsequent sacking in 1990. This was just four months after he was awarded the Wellcome Gold Medal in Pharmacology by the
British Pharmacological Society The British Pharmacological Society is the primary UK learned society for pharmacologists concerned with research into drugs and the way they work. Members work in academia, industry, regulatory agencies and the health services, and many are medi ...
. On 26 May 1994 the book ''Caught in the Act: The Feldberg Investigation'' by Melody MacDonald exposed his alleged malpractice to the world.


References


External links

* Autobiography – Fifty Years On: Looking back on some Developments in Neurohumoral Physiology, Feldberg, Wilhelm; Liverpool University Press, 1982, pl
Professor Feldberg
by the Animal Cruelty Investigation Group {{DEFAULTSORT:Feldberg, Wilhelm 1900 births 1993 deaths 20th-century British biologists British physiologists Commanders Crosses of the Order of Merit of the Federal Republic of Germany Cruelty to animals Fellows of the Royal Society Jewish emigrants from Nazi Germany to the United Kingdom Jewish scientists National Institute for Medical Research faculty Royal Medal winners WEHI alumni Scientists from Hamburg