Werner Otto Carl Creutzfeldt (11 May 1924 – 30 August 2006) was a German professor of internal medicine and an expert in

gastrointestinal The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans and ...

endocrinology Endocrinology (from '' endocrine'' + '' -ology'') is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental event ...

Biography

Creutzfeldt was born in

Berlin Berlin ( , ) is the capital and largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's most populous city, according to population within city limits. One of Germany's sixteen constitue ...

and raised in

Kiel Kiel () is the capital and most populous city in the northern Germany, German state of Schleswig-Holstein, with a population of 246,243 (2021). Kiel lies approximately north of Hamburg. Due to its geographic location in the southeast of the J ...

. During the Second World War, he served in the German Navy from 1942 to 1945. He studied philosophy at the

University of Freiburg The University of Freiburg (colloquially german: Uni Freiburg), officially the Albert Ludwig University of Freiburg (german: Albert-Ludwigs-Universität Freiburg), is a public university, public research university located in Freiburg im Breisg ...

before completing an MD at the

University of Kiel Kiel University, officially the Christian-Albrecht University of Kiel, (german: Christian-Albrechts-Universität zu Kiel, abbreviated CAU, known informally as Christiana Albertina) is a university in the city of Kiel, Germany. It was founded in ...

's Institute of Anatomy in 1950. His first research paper, published in 1953, discussed the

pancreatic The pancreas is an Organ (anatomy), organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdominal cavity, abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine ...

findings in

diabetes mellitus Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ap ...

and

insulinoma An insulinoma is a tumour of the pancreas that is derived from beta cells and secretes insulin. It is a rare form of a neuroendocrine tumour. Most insulinomas are benign in that they grow exclusively at their origin within the pancreas, but a min ...

, which marked a career-long interest in hormonal disorders of the gastrointestinal tract. He began a teaching career in Freiburg before joining the

University of Göttingen The University of Göttingen, officially the Georg August University of Göttingen, (german: Georg-August-Universität Göttingen, known informally as Georgia Augusta) is a public research university in the city of Göttingen, Germany. Founded ...

faculty in 1964 as a full professor. He remained at Göttingen until 1992, where he published over 750 research papers on topics including diabetes,

pituitary In vertebrate anatomy, the pituitary gland, or hypophysis, is an endocrine gland, about the size of a chickpea and weighing, on average, in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain. The hypop ...

function,

neuroendocrine tumour Neuroendocrine tumors (NETs) are neoplasm A neoplasm () is a type of abnormal and excessive growth of tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of t ...

s, the

incretin Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Incretins are released after eating and augment the secretion of insulin released from pancreatic beta cells of the islets of Langerhans by a blood-gl ...

effect,

insulin resistance Insulin resistance (IR) is a pathological condition in which cell (biology), cells fail to respond normally to the hormone insulin. Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood gluco ...

, and

fatty liver disease Fatty liver disease (FLD), also known as hepatic steatosis, is a condition where excess fat builds up in the liver. Often there are no or few symptoms. Occasionally there may be tiredness or pain in the upper right side of the abdomen. Complicat ...

. He was editor-in-chief of the journal ''Digestion'' from 1979 to 1992. In his later career, Creutzfeldt was also a proponent of

medical ethics Medical ethics is an applied branch of ethics which analyzes the practice of clinical medicine and related scientific research. Medical ethics is based on a set of values that professionals can refer to in the case of any confusion or conflict. T ...

, which may have been influenced by his upbringing in the Nazi regime. His father,

Hans Gerhard Creutzfeldt Hans Gerhard Creutzfeldt (June 2, 1885 – December 30, 1964) was a German neurologist and neuropathologist. Although he is typically credited as the physician to first describe the Creutzfeldt–Jakob disease, this has been disputed. He was bor ...

(1885–1964) was a neurologist and co-discoverer of

Creutzfeldt–Jakob disease Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is an invariably fatal degenerative brain disorder. Early symptoms include memory problems, behavioral changes, ...

, and his brother,

Otto Detlev Creutzfeldt Otto Detlev Creutzfeldt (1 April 1927 – 23 January 1992) was a German physiologist and neurologist. He was the son of Hans Gerhard Creutzfeldt and the younger brother of Werner Creutzfeldt, a professor of internal medicine. Career A remarkable ...

, was a neurophysiologist. Werner Creutzfeldt had four children and died in 2006 following a chronic illness.

References

{{DEFAULTSORT:Creutzfeldt, Werner 1924 births 2006 deaths German endocrinologists German medical researchers People from Kiel Academic staff of the University of Göttingen University of Kiel alumni