Werner Arber (born 3 June 1929 in

Gränichen Gränichen is a municipality in the district of Aarau of the canton of Aargau in Switzerland. Geography The river Wyna flows north at first and heads northwest thereafter. The valley has an average width of about . On both sides of the valley ...

, Aargau) is a

Swiss Swiss may refer to: * the adjectival form of Switzerland * Swiss people Places * Swiss, Missouri * Swiss, North Carolina *Swiss, West Virginia * Swiss, Wisconsin Other uses *Swiss-system tournament, in various games and sports *Swiss Internation ...

microbiologist and

geneticist A geneticist is a biologist or physician who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a scientist or a lecturer. Geneticists may perform general research on genetic processe ...

. Along with American researchers Hamilton Smith and

Daniel Nathans Daniel Nathans (October 30, 1928 – November 16, 1999) was an American microbiologist. He shared the 1978 Nobel Prize in Physiology or Medicine for the discovery of restriction enzymes and their application in restriction mapping. Early life a ...

, Werner Arber shared the 1978

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accord ...

for the discovery of

restriction endonucleases A restriction enzyme, restriction endonuclease, REase, ENase or'' restrictase '' is an enzyme that cleaves DNA into fragments at or near specific recognition sites within molecules known as restriction sites. Restriction enzymes are one class o ...

. Their work would lead to the development of

recombinant DNA Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) that bring together genetic material from multiple sources, creating sequences that would not otherwise be fo ...

technology.

Life and career

Arber studied

chemistry Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions ...

and

physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which r ...

at the Swiss Federal Institute of Technology in

Zürich Zürich () is the list of cities in Switzerland, largest city in Switzerland and the capital of the canton of Zürich. It is located in north-central Switzerland, at the northwestern tip of Lake Zürich. As of January 2020, the municipality has 43 ...

from 1949 to 1953. Late in 1953, he took an assistantship for electron microscopy at the

University of Geneva The University of Geneva (French: ''Université de Genève'') is a public research university located in Geneva, Switzerland. It was founded in 1559 by John Calvin as a theological seminary. It remained focused on theology until the 17th centur ...

, in time left the electron microscope, went on to research

bacteriophage A bacteriophage (), also known informally as a ''phage'' (), is a duplodnaviria virus that infects and replicates within bacteria and archaea. The term was derived from "bacteria" and the Greek φαγεῖν ('), meaning "to devour". Bacteri ...

s and write his dissertation on defective

lambda Lambda (}, ''lám(b)da'') is the 11th letter of the Greek alphabet, representing the voiced alveolar lateral approximant . In the system of Greek numerals, lambda has a value of 30. Lambda is derived from the Phoenician Lamed . Lambda gave rise ...

prophage mutants. In his Nobel Autobiography, he writes:

In the summer of 1956, we learned about experiments made by Larry Morse and Esther and Joshua Lederberg on the lambda-mediated transduction (gene transfer from one bacterial strain to another by a bacteriophage serving as vector) of bacterial determinants for galactose fermentation. Since these investigators had encountered defective lysogenic strains among their transductants, we felt that such strains should be included in the collection of lambda prophage mutants under study in our laboratory. Very rapidly, thanks to the stimulating help by
Jean Weigle Jean-Jacques Weigle (9 July 1901 – 28 December 1968) was a Swiss molecular biologist at Caltech and formerly a physicist at the University of Geneva from 1931 to 1948. He is known for his major contributions on field of bacteriophage λ research, ...
and
Grete Kellenberger Grete or Grethe is a feminine given name, a derivate of Margaret. It is most often used in Scandinavia (not including Sweden), Estonia, and German-speaking Europe. People Given name * Grete Berget (1954–2017), Norwegian politician * Grete Da ...
, this turned out to be extremely fruitful. ... This was the end of my career as an electron microscopist and in chosing genetic and physiological approaches I became a molecular geneticist.

He received his doctorate in 1958 from the University of Geneva. Arber then worked at the

University of Southern California The University of Southern California (USC, SC, or Southern Cal) is a Private university, private research university in Los Angeles, California, United States. Founded in 1880 by Robert M. Widney, it is the oldest private research university in C ...

in phage genetics with Gio ("Joe") Bertani starting in the summer of 1958. Late in 1959 he accepted an offer to return to Geneva at the beginning of 1960, but only after spending "several very fruitful weeks" at each of the laboratories of

Gunther Stent Gunther S. Stent (28 March 1924 – 12 June 2008) was Graduate Professor of Molecular Biology at the University of California, Berkeley. One of the early bacteriophage biologists, he was known also for his studies on the metabolism of bacter ...

(

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...

Joshua Lederberg Joshua () or Yehoshua ( ''Yəhōšuaʿ'', Tiberian: ''Yŏhōšuaʿ,'' lit. 'Yahweh is salvation') ''Yēšūaʿ''; syr, ܝܫܘܥ ܒܪ ܢܘܢ ''Yəšūʿ bar Nōn''; el, Ἰησοῦς, ar , يُوشَعُ ٱبْنُ نُونٍ '' Yūšaʿ ...

and

Esther Lederberg Esther Miriam Zimmer Lederberg (December 18, 1922 – November 11, 2006) was an American microbiologist and a pioneer of bacterial genetics. She discovered the bacterial virus λ and the bacterial fertility factor F, devised the first impl ...

(

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

) and

Salvador Luria Salvador Edward Luria (August 13, 1912 – February 6, 1991) was an Italian microbiologist, later a Naturalized citizen of the United States#Naturalization, naturalized U.S. citizen. He won the Nobel Prize in Physiology or Medicine in 1969, with ...

(

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the ...

). Arber notes that it was in 1963, while he was a researcher in Stent's Berkeley lab, when experiments produced the first evidence that modification in ''E. coli'' B and K is brought about by nucleotide methylation. Back at the University of Geneva, Arber worked in a laboratory in the basement of the Physics Institute, where he carried out productive research and hosted "a number of first class graduate students, postdoctoral fellows and senior scientists." including Daisy Roulland Dussoix, whose work helped him to later obtain the Nobel Prize. In 1965, the University of Geneva promoted him to Extraordinary Professor for Molecular Genetics. In 1971, after spending a year as a visiting Miller Professor in the Department of

Molecular Biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

Berkeley Berkeley most often refers to: *Berkeley, California, a city in the United States **University of California, Berkeley, a public university in Berkeley, California * George Berkeley (1685–1753), Anglo-Irish philosopher Berkeley may also refer ...

, Arber moved to the

University of Basel The University of Basel (Latin: ''Universitas Basiliensis'', German: ''Universität Basel'') is a university in Basel, Switzerland. Founded on 4 April 1460, it is Switzerland's oldest university and among the world's oldest surviving universit ...

. In Basel, he was one of the first persons to work in the newly constructed Biozentrum, which housed the departments of biophysics, biochemistry, microbiology, structural biology, cell biology and pharmacology and was thus conducive to interdisciplinary research. On 27 occasions since 1981, Werner Arber has shared his expertise and passion for science with young scientists at the

Lindau Nobel Laureate Meetings The Lindau Nobel Laureate Meetings are annual scientific conferences held in Lindau, Bavaria, Germany, since 1951. Their aim is to bring together Nobel laureates and young scientists to foster scientific exchange between different generations, ...

. Werner Arber is member of th
World Knowledge Dialogue
Scientific Board and of the

Pontifical Academy of Sciences The Pontifical Academy of Sciences ( it, Pontificia accademia delle scienze, la, Pontificia Academia Scientiarum) is a Academy of sciences, scientific academy of the Vatican City, established in 1936 by Pope Pius XI. Its aim is to promote the ...

since 1981. In 1981, Arber became a founding member of the

World Cultural Council The World Cultural Council is an international organization whose goals are to promote cultural values, goodwill and philanthropy among individuals. The organization founded in 1981 and based in Mexico, has held a yearly award ceremony since 198 ...

. He was elected a Fellow of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

in 1984. Pope Benedict XVI appointed him as President of the

in January 2011, making him the first Protestant to hold the position. In 2017, Arber retired as President of the Pontifical Academy of Sciences and was replaced by German scientist

Joachim von Braun Joachim von Braun (born July 10, 1950) is a German agricultural scientist and currently director of a department of the Center for Development Research at the University of Bonn and President of the Pontifical Academy of Sciences. Previously, vo ...

Personal life

Arber is married and has two daughters. Arber is a Christian and theistic evolutionist, stating "The most primitive cells may require at least several hundred different specific biological macromolecules. How such already quite complex structures may have come together, remains a mystery to me. The possibility of the existence of a Creator, of God, represents to me a satisfactory solution to this problem." In addition, he has affirmed: "I know that the concept of God helped me to master many questions in life; it guides me in critical situations, and I see it confirmed in many deep insights into the beauty of the functioning of the world."Arber, W. 1992. ''The Existence of a Creator Represents a Satisfactory Solution.'' In Margenau, H. and R. A. Varghese (eds.), ''Cosmos, Bios, Theos: Scientists Reflect on Science, God, and the Origins of the Universe, Life, and Homo sapiens.'' La Salle, IL: Open Court, p. 143.

References

External links

*
Official Biography from the Pontifical Academy of SciencesFree to View Video Interview with Werner Arber
provided by the Vega Science Trust. {{DEFAULTSORT:Arber, Werner 1929 births Living people People from Aarau District Swiss microbiologists Founding members of the World Cultural Council Foreign associates of the National Academy of Sciences History of biotechnology Swiss biologists Phage workers Nobel laureates in Physiology or Medicine University of Geneva alumni University of Southern California faculty University of Geneva faculty Swiss Nobel laureates Swiss Protestants Presidents of the Pontifical Academy of Sciences Members of the European Molecular Biology Organization ETH Zurich alumni Recipients of the Great Cross of the National Order of Scientific Merit (Brazil) Fellows of the American Academy of Arts and Sciences Biozentrum University of Basel Theistic evolutionists Fellows of the American Academy of Microbiology

Life and career

Personal life

References

Further reading

External links