Water for injection is
water
Water (chemical formula ) is an inorganic, transparent, tasteless, odorless, and nearly colorless chemical substance, which is the main constituent of Earth's hydrosphere and the fluids of all known living organisms (in which it acts as a ...
of extra high quality without significant contamination.
A
sterile version is used for making solutions that will be given by
injection
Injection or injected may refer to:
Science and technology
* Injective function, a mathematical function mapping distinct arguments to distinct values
* Injection (medicine), insertion of liquid into the body with a syringe
* Injection, in broadca ...
.
Before such use other substances generally must be added to make the solution more or less
isotonic.
It can be given by
injection into a vein
Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutri ...
,
muscle
Skeletal muscles (commonly referred to as muscles) are organs of the vertebrate muscular system and typically are attached by tendons to bones of a skeleton. The muscle cells of skeletal muscles are much longer than in the other types of muscl ...
, or
under the skin.
A non-sterile version may be used in manufacturing with
sterilization occurring later in the production process.
[
If it is given by injection into a vein without making it approximately isotonic, breakdown of red blood cells may occur.][ This can then result in ]kidney problems
Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...
.[ Excessive amount may also result in ]fluid overload
Hypervolemia, also known as fluid overload, is the medical condition where there is too much fluid in the blood. The opposite condition is hypovolemia, which is too little fluid volume in the blood. Fluid volume excess in the intravascular comp ...
.[ Water for injection is generally made by ]distillation
Distillation, or classical distillation, is the process of separation process, separating the components or substances from a liquid mixture by using selective boiling and condensation, usually inside an apparatus known as a still. Dry distilla ...
or reverse osmosis
Reverse osmosis (RO) is a water purification process that uses a partially permeable membrane to separate ions, unwanted molecules and larger particles from drinking water. In reverse osmosis, an applied pressure is used to overcome osmotic pre ...
.[ It should contain less than a mg of elements other than water per 100 ml.][ Versions with agents that stop bacterial growth are also available.]
It is on the World Health Organization's List of Essential Medicines
The WHO Model List of Essential Medicines (aka Essential Medicines List or EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health ...
. Water for injection is available over the counter
Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescr ...
in the United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...
.[
]
Other names
Water for injection is also known as or .
References
External links
Inspection Technical Guides Water for Pharmaceutical Use
Guideline on the quality of water for pharmaceutical use (EMA, European Medicines Agency)
*
{{portal bar, Medicine
Intravenous fluids
Water
Wikipedia medicine articles ready to translate
World Health Organization essential medicines