Pre-mRNA-splicing regulator WTAP is a
protein that in humans is encoded by the ''WTAP''
gene.
The Wilms tumor suppressor gene WT1 appears to play a role in both
transcriptional
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules calle ...
and
posttranscriptional regulation
Post-transcriptional regulation is the control of gene expression at the RNA level. It occurs once the RNA polymerase has been attached to the gene's promoter and is synthesizing the nucleotide sequence. Therefore, as the name indicates, it occur ...
of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the
nucleoplasm as well as in
speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.
Interactions
WTAP has been shown to
interact with
WT1.
References
Further reading
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