Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''WNK3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
WNK3 is a protein belonging to the 'with no lysine' family of
serine-threonine protein kinases. These family members lack the catalytic
lysine
Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins. It contains an α-amino group (which is in the protonated form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −C ...
in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular
Ca2+ transport pathway, and it plays a role in the increase of cell survival in a
caspase 3
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the ''CASP3'' gene. ''CASP3'' orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are als ...
dependent pathway.
References
Further reading
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EC 2.7.11
{{gene-X-stub