The WIPI protein family (WD-repeat protein Interacting with PhosphoInositides) is an evolutionarily conserved family of proteins.
WIPI proteins contain a
WD repeat
The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Protein tandem repeats, Tandem copies of these repeats ...
domain that folds into a 7-bladed
beta-propeller
In structural biology, a beta-propeller (β-propeller) is a type of all-β protein architecture characterized by 4 to 8 highly symmetrical blade-shaped beta sheets arranged toroidally around a central axis. Together the beta-sheets form a funnel ...
that functions in
autophagy,
and contain a conserved motif for interaction with phospholipids.
Members of this family include:
References
Protein families
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