WD repeat-containing protein 5 is a
protein that in humans is encoded by the ''WDR5''
gene.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
Interactions
WDR5 has been shown to
interact
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with
Host cell factor C1 and
MLL.
[ It also interacts with the long non-coding RNA HOTTIP and to the lncRNA NeST.]
References
Further reading
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