Vindesine, also termed Eldisine, is a
semisynthetic vinca alkaloid derived from the flowering plant ''
Catharanthus roseus.''
Like the natural (e.g.
vinblastine and
vincristine) and semisynthetic vinca alkaloids (e.g.
vinorelbine and
vinflunine
Vinflunine (INN, trade name Javlor) is a novel fluorinated ''vinca'' alkaloid derivative undergoing research for the treatment of bladder cancer. It was originally discovered by the team of the Professor Jean-Claude Jacquesy (UMR CNRS 6514 – P ...
) derived from this plant, vindesine is an
inhibitor of mitosis that is used as a
chemotherapy drug.
By inhibiting
mitosis
In cell biology, mitosis () is a part of the cell cycle in which replicated chromosomes are separated into two new nuclei. Cell division by mitosis gives rise to genetically identical cells in which the total number of chromosomes is mainta ...
, vinedsine blocks the proliferation of cells, particularly the rapidly proliferation cells of certain types of cancer. It is used, generally in combination with other chemotherapeutic drugs, in the treatment of various malignancies such as
leukaemia,
lymphoma,
melanoma
Melanoma, also redundantly known as malignant melanoma, is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. Melanomas typically occur in the skin, but may rarely occur in the mouth, intestines, or eye ( ...
,
breast cancer, and
lung cancer.
References
Vinca alkaloids
Mitotic inhibitors
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