Vesicle-associated membrane protein 8 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''VAMP8''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.
Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.
Interactions
Vesicle-associated membrane protein 8 has been shown to
interact
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with
STX4
Syntaxin-4 is a protein that in humans is encoded by the ''STX4'' gene.
Interactions
STX4 has been shown to interact with:
* Gelsolin,
* NAPA,
* RAB4A,
* SNAP-25,
* SNAP23,
* STXBP1,
* STXBP5,
* Syntaxin binding protein 3,
* TXLNB, ...
,
SNAP23
Synaptosomal-associated protein 23 is a protein that in humans is encoded by the ''SNAP23'' gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Function
Specificity of vesicular tran ...
,
STX1A
Syntaxin-1A is a protein that in humans is encoded by the ''STX1A'' gene.
Function
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localiz ...
,
References
Further reading
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{{PDB Gallery, geneid=8673