''Vitis vinifera'', the common grape vine, is a species of

flowering plant Flowering plants are plants that bear flowers and fruits, and form the clade Angiospermae (), commonly called angiosperms. The term "angiosperm" is derived from the Greek words ('container, vessel') and ('seed'), and refers to those plants th ...

, native to the Mediterranean region,

Central Europe Central Europe is an area of Europe between Western Europe and Eastern Europe, based on a common historical, social and cultural identity. The Thirty Years' War (1618–1648) between Catholicism and Protestantism significantly shaped the area' ...

, and southwestern

Asia Asia (, ) is one of the world's most notable geographical regions, which is either considered a continent in its own right or a subcontinent of Eurasia, which shares the continental landmass of Afro-Eurasia with Africa. Asia covers an area ...

, from

Morocco Morocco (),, ) officially the Kingdom of Morocco, is the westernmost country in the Maghreb region of North Africa. It overlooks the Mediterranean Sea to the north and the Atlantic Ocean to the west, and has land borders with Algeria to ...

and

Portugal Portugal, officially the Portuguese Republic ( pt, República Portuguesa, links=yes ), is a country whose mainland is located on the Iberian Peninsula of Southwestern Europe, and whose territory also includes the Atlantic archipelagos of ...

north to southern

Germany Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...

and east to northern

Iran Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...

. There are currently between 5,000 and 10,000 varieties of ''Vitis vinifera'' grapes though only a few are of commercial significance for wine and table grape production. The wild grape is often classified as ''Vitis vinifera'' ''sylvestris'' (in some classifications considered ''Vitis sylvestris''), with ''Vitis vinifera'' ''vinifera'' restricted to cultivated forms. Domesticated vines have

hermaphrodite In reproductive biology, a hermaphrodite () is an organism that has both kinds of reproductive organs and can produce both gametes associated with male and female sexes. Many Taxonomy (biology), taxonomic groups of animals (mostly invertebrate ...

flowers, but ''sylvestris'' is

dioecious Dioecy (; ; adj. dioecious , ) is a characteristic of a species, meaning that it has distinct individual organisms (unisexual) that produce male or female gametes, either directly (in animals) or indirectly (in seed plants). Dioecious reproductio ...

(

male Male (symbol: ♂) is the sex of an organism that produces the gamete (sex cell) known as sperm, which fuses with the larger female gamete, or ovum, in the process of fertilization. A male organism cannot reproduce sexually without access to ...

and

female Female (Venus symbol, symbol: ♀) is the sex of an organism that produces the large non-motile ovum, ova (egg cells), the type of gamete (sex cell) that fuses with the Sperm, male gamete during sexual reproduction. A female has larger gamet ...

flowers on separate plants) and pollination is required for fruit to develop. Grapes can be eaten fresh or dried to produce raisins, sultanas, and currants. Grape leaves are used in the cuisine of many cultures. The fresh grapes can also be processed into juice that is fermented to make

wine Wine is an alcoholic drink typically made from fermented grapes. Yeast consumes the sugar in the grapes and converts it to ethanol and carbon dioxide, releasing heat in the process. Different varieties of grapes and strains of yeasts are m ...

and

vinegar Vinegar is an aqueous solution of acetic acid and trace compounds that may include flavorings. Vinegar typically contains 5–8% acetic acid by volume. Usually, the acetic acid is produced by a double fermentation, converting simple sugars to et ...

. Cultivars of ''Vitis vinifera'' form the basis of the majority of wines produced around the world. All of the familiar wine varieties belong to ''Vitis vinifera'', which is cultivated on every continent except for

Antarctica Antarctica () is Earth's southernmost and least-populated continent. Situated almost entirely south of the Antarctic Circle and surrounded by the Southern Ocean, it contains the geographic South Pole. Antarctica is the fifth-largest contine ...

, and in all the major wine regions of the world.

History

Prehistory

Wild grapes were harvested by neolithic foragers and early farmers. For thousands of years, the

fruit In botany, a fruit is the seed-bearing structure in flowering plants that is formed from the ovary after flowering. Fruits are the means by which flowering plants (also known as angiosperms) disseminate their seeds. Edible fruits in particu ...

has been harvested for both medicinal and nutritional value; its history is intimately entwined with the

history of wine Wine has been produced for thousands of years, with evidence of ancient wine production in Georgia from BC (the earliest known traces of wine), West Azerbaijan province of Iran from BC, Armenia from BC (large-scale production), and Sicil ...

. Changes in pip (seed) shape (narrower in domesticated forms) and distribution point to domestication occurring about 3500–3000 BC, in southwest Asia,

South Caucasus The South Caucasus, also known as Transcaucasia or the Transcaucasus, is a geographical region on the border of Eastern Europe and Western Asia, straddling the southern Caucasus Mountains. The South Caucasus roughly corresponds to modern Arme ...

( Georgia), or the Western Black Sea shore region (

Romania Romania ( ; ro, România ) is a country located at the crossroads of Central Europe, Central, Eastern Europe, Eastern, and Southeast Europe, Southeastern Europe. It borders Bulgaria to the south, Ukraine to the north, Hungary to the west, S ...

and

Bulgaria Bulgaria (; bg, България, Bǎlgariya), officially the Republic of Bulgaria,, ) is a country in Southeast Europe. It is situated on the eastern flank of the Balkans, and is bordered by Romania to the north, Serbia and North Macedon ...

). The earliest evidence of domesticated grapes has been found at Gadachrili Gora, near the village of Imiri,

Marneuli Municipality Marneuli ( ka, მარნეულის მუნიციპალიტეტი, az, Marneuli Bələdiyyəsi) is a municipality in Georgia, in the region of Kvemo Kartli. Its administrative center and main town is Marneuli. Location ...

, in southeastern Georgia; carbon-dating points to the date of about 6000 BC. Grape pips dating back to the 5th–4th millennium BC were also found in Shulaveri; others dating back to the 4th millennium BC were also found in Khizanaant Gora, all in the country of Georgia.

Antiquity

Cultivation of the domesticated grape spread to other parts of the

Old World The "Old World" is a term for Afro-Eurasia that originated in Europe , after Europeans became aware of the existence of the Americas. It is used to contrast the continents of Africa, Europe, and Asia, which were previously thought of by the ...

in pre-historic or early historic times. The first written accounts of grapes and wine can be found in the ''

Epic of Gilgamesh The ''Epic of Gilgamesh'' () is an epic poetry, epic poem from ancient Mesopotamia, and is regarded as the earliest surviving notable literature and the second oldest religious text, after the Pyramid Texts. The literary history of Gilgamesh ...

'', an ancient

Sumer Sumer () is the earliest known civilization in the historical region of southern Mesopotamia (south-central Iraq), emerging during the Chalcolithic and early Bronze Ages between the sixth and fifth millennium BC. It is one of the cradles of c ...

ian text from the 3rd millennium BC. There are also numerous hieroglyphic references from ancient Egypt, according to which wine was reserved exclusively for priests, state functionaries and the pharaoh. Cup vintage Cdm Paris 320 n4

Hesiod Hesiod (; grc-gre, Ἡσίοδος ''Hēsíodos'') was an ancient Greek poet generally thought to have been active between 750 and 650 BC, around the same time as Homer. He is generally regarded by western authors as 'the first written poet i ...

in his

Works and Days ''Works and Days'' ( grc, Ἔργα καὶ Ἡμέραι, Érga kaì Hēmérai)The ''Works and Days'' is sometimes called by the Latin translation of the title, ''Opera et Dies''. Common abbreviations are ''WD'' and ''Op''. for ''Opera''. is a ...

gives detailed descriptions of grape harvests and wine making techniques, and there are also many references in

Homer Homer (; grc, Ὅμηρος , ''Hómēros'') (born ) was a Greek poet who is credited as the author of the ''Iliad'' and the ''Odyssey'', two epic poems that are foundational works of ancient Greek literature. Homer is considered one of the ...

. Greek colonists then introduced these practices in their colonies, especially in southern Italy (Magna Grecia), which was even known as Enotria due to its propitious climate. The

Etruscans The Etruscan civilization () was developed by a people of Etruria in ancient Italy with a common language and culture who formed a federation of city-states. After conquering adjacent lands, its territory covered, at its greatest extent, rou ...

improved wine making techniques and developed an export trade even beyond the Mediterranean basin. The ancient Romans further developed the techniques learnt from the Etruscans, as shown by numerous works of literature containing information that is still valid today: '' De Agri Cultura'' (around 160 BC) by

Cato the Elder Marcus Porcius Cato (; 234–149 BC), also known as Cato the Censor ( la, Censorius), the Elder and the Wise, was a Roman soldier, senator, and historian known for his conservatism and opposition to Hellenization. He was the first to write histo ...

, '' De re rustica'' by Marcus Terentius Varro, the ''

Georgics The ''Georgics'' ( ; ) is a poem by Latin poet Virgil, likely published in 29 BCE. As the name suggests (from the Greek word , ''geōrgika'', i.e. "agricultural (things)") the subject of the poem is agriculture; but far from being an example ...

'' by

Virgil Publius Vergilius Maro (; traditional dates 15 October 7021 September 19 BC), usually called Virgil or Vergil ( ) in English, was an ancient Roman poet of the Augustan period. He composed three of the most famous poems in Latin literature: t ...

and '' De re rustica'' by Columella. During the 3rd and 4th centuries AD, the long crisis of the Roman Empire generated instability in the countryside which led to a reduction of viticulture in general, which was mainly sustained only close to towns and cities and along coastlines.

Medieval era

Between the 5th and 10th centuries, viticulture was sustained almost exclusively by the different religious orders in monasteries. The Benedictines and others extended the grape growing limit northwards and also planted new vineyards at higher altitudes than was customary before. Apart from 'ecclesiastical' viticulture, there also developed, especially in France, a 'noble' viticulture, practiced by the aristocracy as a symbol of prestige. Grape growing was a significant economic activity in the Middle east up to the 7th century, when the expansion of Islam caused it to decline. Vergy-vignes

Early modern period

Between the Low Middle Ages and the Renaissance, viticulture began to flourish again. Demographic pressure, population concentration in towns and cities, and the increased spending power of artisans and merchants gave rise to increased investment in viticulture, which became economically feasible once more. Much was written during the Renaissance on grape growing and wine production, favouring a more scientific approach. This literature can be considered the origin of modern

ampelography Ampelography ( ἄμπελος, "vine" + γράφος, "writing") is the field of botany concerned with the identification and classification of grapevines, ''Vitis'' spp. Traditionally this has been done by comparing the shape and colour of the ...

. Grapes followed European colonies around the world, coming to

North America North America is a continent in the Northern Hemisphere and almost entirely within the Western Hemisphere. It is bordered to the north by the Arctic Ocean, to the east by the Atlantic Ocean, to the southeast by South America and the Car ...

around the 17th century, and to

Africa Africa is the world's second-largest and second-most populous continent, after Asia in both cases. At about 30.3 million km2 (11.7 million square miles) including adjacent islands, it covers 6% of Earth's total surface area ...

South America South America is a continent entirely in the Western Hemisphere and mostly in the Southern Hemisphere, with a relatively small portion in the Northern Hemisphere at the northern tip of the continent. It can also be described as the southe ...

and

Australia Australia, officially the Commonwealth of Australia, is a Sovereign state, sovereign country comprising the mainland of the Australia (continent), Australian continent, the island of Tasmania, and numerous List of islands of Australia, sma ...

. In North America it formed hybrids with native species from the genus ''Vitis''; some of these were intentional hybrids created to combat ''

phylloxera Grape phylloxera is an insect pest of commercial grapevines worldwide, originally native to eastern North America. Grape phylloxera (''Daktulosphaira vitifoliae'' (Fitch 1855) belong to the family Phylloxeridae, within the order Hemiptera, bugs ...

'', an

insect Insects (from Latin ') are pancrustacean hexapod invertebrates of the class Insecta. They are the largest group within the arthropod phylum. Insects have a chitinous exoskeleton, a three-part body ( head, thorax and abdomen), three pairs ...

pest which affected the European grapevine to a much greater extent than North American ones and in fact managed to devastate European wine production in a matter of years. Later, North American rootstocks became widely used to graft ''V. vinifera'' cultivars so as to withstand the presence of phylloxera.

Contemporary period

In the second half of the 20th century there was a shift in attitude in viticulture from traditional techniques to the scientific method based on fields such as microbiology, chemistry and ampelography. This change came about also due to changes in economic and cultural aspects and in the way of life and in the consumption habits of wide sectors of the population starting to demand quality products. In 2007, ''Vitis vinifera'' was the fourth angiosperm species whose genome was completely sequenced. These data contributed significantly to understanding the evolution of plants and also how the aromatic characteristics of wine are determined in part by the plant's genes. This work was a collaboration between Italian researchers (Consorzio Interuniversitario Nazionale per la Biologia Molecolare delle Piante, Istituto di Genomica Applicata) and French researchers (

Genoscope The French National Sequencing Center (Genoscope) was created in 1996 in Évry, France. It has been involved in the sequencing of the human genome The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA withi ...

and Institut National de la Recherche Agronomique). Also in 2007, scientists from

's Commonwealth Scientific and Industrial Research Organisation (CSIRO), working in the Cooperative Research Centre for Viticulture, reported that their "research suggests that extremely rare and independent mutations in two genes 'VvMYBA1'' and ''VvMYBA2'' of red grapesproduced a single white grapevine that was the parent of almost all of the world's white grape varieties. If only one gene had been mutated, most grapes would still be red and we would not have the more than 3000 white grape cultivars available today."

Description

It is a

liana A liana is a long- stemmed, woody vine that is rooted in the soil at ground level and uses trees, as well as other means of vertical support, to climb up to the canopy in search of direct sunlight. The word ''liana'' does not refer to a ta ...

growing tall at a fast rate. Having a flaky

bark Bark may refer to: * Bark (botany), an outer layer of a woody plant such as a tree or stick * Bark (sound), a vocalization of some animals (which is commonly the dog) Places * Bark, Germany * Bark, Warmian-Masurian Voivodeship, Poland Arts, ...

, its

leaves A leaf (plural, : leaves) is any of the principal appendages of a vascular plant plant stem, stem, usually borne laterally aboveground and specialized for photosynthesis. Leaves are collectively called foliage, as in "autumn foliage", wh ...

are alternate, palmately lobed,

deciduous In the fields of horticulture and Botany, the term ''deciduous'' () means "falling off at maturity" and "tending to fall off", in reference to trees and shrubs that seasonally shed leaves, usually in the autumn; to the shedding of petals, aft ...

, with 3 to 5 pointed lobes, coarsely prickly-toothed leaf margins and a heart-shaped foot, long and broad. They are glossy dark green on top, light green below, usually hairless. The vine attaches to supports by

tendrils In botany, a tendril is a specialized stem, leaf or petiole with a threadlike shape used by climbing plants for support and attachment, as well as cellular invasion by parasitic plants such as ''Cuscuta''. There are many plants that have tendr ...

. The stems, called twigs, grow through their tip, the cauline apex. A branch consists of several internodes separated by knots, which grow the leaves, flowers, tendrils and between-core and where to train future buds. During their hardening, the twigs become woody branches that can reach a great length. Its roots usually sink to a depth of 2 to 5 meters and sometimes up to 12–15 meters or even more. The species typically occurs in humid forests and streamsides.

Inflorescences

Their flowers, small and greenish to white, are grouped in

inflorescence An inflorescence is a group or cluster of flowers arranged on a stem that is composed of a main branch or a complicated arrangement of branches. Morphologically, it is the modified part of the shoot of seed plants where flowers are formed o ...

s and their fruits, of different shapes depending on the subspecies, are berries grouped in clusters. The calyx is single-leaf with 5 short, deciduous teeth. The corolla consists of five petals, fused at the top and base, and then falls off in its entirety. Opposite the petals there are five

stamen The stamen (plural ''stamina'' or ''stamens'') is the pollen-producing reproductive organ of a flower. Collectively the stamens form the androecium., p. 10 Morphology and terminology A stamen typically consists of a stalk called the filame ...

s interspersed with glands. The upper

ovary The ovary is an organ in the female reproductive system that produces an ovum. When released, this travels down the fallopian tube into the uterus, where it may become fertilized by a sperm. There is an ovary () found on each side of the body. ...

bears a very short style with a button-shaped stigma. The wild vine is a

plant, the male and female flowers arise on different plants, but the cultivated forms are hermaphroditic, allowing

self-pollination Self-pollination is a form of pollination in which pollen from the same plant arrives at the Stigma (botany), stigma of a flower (in flowering plants) or at the ovule (in gymnosperms). There are two types of self-pollination: in autogamy, pollen i ...

. The

is a

berry A berry is a small, pulpy, and often edible fruit. Typically, berries are juicy, rounded, brightly colored, sweet, sour or tart, and do not have a stone or pit, although many pips or seeds may be present. Common examples are strawberries, raspb ...

, known as a

grape A grape is a fruit, botanically a berry, of the deciduous woody vines of the flowering plant genus ''Vitis''. Grapes are a non- climacteric type of fruit, generally occurring in clusters. The cultivation of grapes began perhaps 8,000 years ago, ...

that is ovoid or globular, dark blue or greenish, usually 2-locular with 5 seeds; in the wild species it is diameter and ripens dark purple to blackish with a pale wax bloom; in cultivated plants it is usually much larger, up to long, and can be green, red, or purple (black).

Distribution

''V. vinifera'' accounts for the majority of world wine production; all of the most familiar grape varieties used for wine production belong to ''V. vinifera''. In

Europe Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a Continent#Subcontinents, subcontinent of Eurasia ...

, ''Vitis vinifera'' is concentrated in the central and southern regions; in

, in the western regions such as

Anatolia Anatolia, tr, Anadolu Yarımadası), and the Anatolian plateau, also known as Asia Minor, is a large peninsula in Western Asia and the westernmost protrusion of the Asian continent. It constitutes the major part of modern-day Turkey. The re ...

, the

Caucasus The Caucasus () or Caucasia (), is a region between the Black Sea and the Caspian Sea, mainly comprising Armenia, Azerbaijan, Georgia, and parts of Southern Russia. The Caucasus Mountains, including the Greater Caucasus range, have historically ...

, the

Middle East The Middle East ( ar, الشرق الأوسط, ISO 233: ) is a geopolitical region commonly encompassing Arabian Peninsula, Arabia (including the Arabian Peninsula and Bahrain), Anatolia, Asia Minor (Asian part of Turkey except Hatay Pro ...

, and in

China China, officially the People's Republic of China (PRC), is a country in East Asia. It is the world's most populous country, with a population exceeding 1.4 billion, slightly ahead of India. China spans the equivalent of five time zones and ...

; in

, along the northern

Mediterranean The Mediterranean Sea is a sea connected to the Atlantic Ocean, surrounded by the Mediterranean Basin and almost completely enclosed by land: on the north by Western and Southern Europe and Anatolia, on the south by North Africa, and on the e ...

coast and in

South Africa South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. It is bounded to the south by of coastline that stretch along the South Atlantic and Indian Oceans; to the north by the neighbouring countri ...

; in

, in

California California is a U.S. state, state in the Western United States, located along the West Coast of the United States, Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the List of states and territori ...

and also other areas like

Michigan Michigan () is a state in the Great Lakes region of the upper Midwestern United States. With a population of nearly 10.12 million and an area of nearly , Michigan is the 10th-largest state by population, the 11th-largest by area, and the ...

New Mexico ) , population_demonym = New Mexican ( es, Neomexicano, Neomejicano, Nuevo Mexicano) , seat = Santa Fe , LargestCity = Albuquerque , LargestMetro = Tiguex , OfficialLang = None , Languages = English, Spanish ( New Mexican), Navajo, Ker ...

New York New York most commonly refers to: * New York City, the most populous city in the United States, located in the state of New York * New York (state), a state in the northeastern United States New York may also refer to: Film and television * '' ...

Oregon Oregon () is a U.S. state, state in the Pacific Northwest region of the Western United States. The Columbia River delineates much of Oregon's northern boundary with Washington (state), Washington, while the Snake River delineates much of it ...

Washington state Washington (), officially the State of Washington, is a state in the Pacific Northwest region of the Western United States. Named for George Washington—the first U.S. president—the state was formed from the western part of the Washington ...

British Columbia British Columbia (commonly abbreviated as BC) is the westernmost province of Canada, situated between the Pacific Ocean and the Rocky Mountains. It has a diverse geography, with rugged landscapes that include rocky coastlines, sandy beaches, ...

Ontario Ontario ( ; ) is one of the thirteen provinces and territories of Canada.Ontario is located in the geographic eastern half of Canada, but it has historically and politically been considered to be part of Central Canada. Located in Central Ca ...

and

Québec Quebec ( ; )According to the Government of Canada, Canadian government, ''Québec'' (with the acute accent) is the official name in Canadian French and ''Quebec'' (without the accent) is the province's official name in Canadian English is ...

; in

Chile Chile, officially the Republic of Chile, is a country in the western part of South America. It is the southernmost country in the world, and the closest to Antarctica, occupying a long and narrow strip of land between the Andes to the east a ...

Argentina Argentina (), officially the Argentine Republic ( es, link=no, República Argentina), is a country in the southern half of South America. Argentina covers an area of , making it the second-largest country in South America after Brazil, th ...

Uruguay Uruguay (; ), officially the Oriental Republic of Uruguay ( es, República Oriental del Uruguay), is a country in South America. It shares borders with Argentina to its west and southwest and Brazil to its north and northeast; while bordering ...

Peru , image_flag = Flag of Peru.svg , image_coat = Escudo nacional del Perú.svg , other_symbol = Great Seal of the State , other_symbol_type = Seal (emblem), National seal , national_motto = "Fi ...

and

Brazil Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area ...

; and in

Oceania Oceania (, , ) is a region, geographical region that includes Australasia, Melanesia, Micronesia, and Polynesia. Spanning the Eastern Hemisphere, Eastern and Western Hemisphere, Western hemispheres, Oceania is estimated to have a land area of ...

and

New Zealand New Zealand ( mi, Aotearoa ) is an island country in the southwestern Pacific Ocean. It consists of two main landmasses—the North Island () and the South Island ()—and over 700 smaller islands. It is the sixth-largest island count ...

Cultivation

Use of

s is known to date back to

Neolithic The Neolithic period, or New Stone Age, is an Old World archaeological period and the final division of the Stone Age. It saw the Neolithic Revolution, a wide-ranging set of developments that appear to have arisen independently in several parts ...

times, following the discovery in 1996 of 7,000-year-old

storage jars in present-day northern

. Further evidence shows the

Mesopotamia Mesopotamia ''Mesopotamíā''; ar, بِلَاد ٱلرَّافِدَيْن or ; syc, ܐܪܡ ܢܗܪ̈ܝܢ, or , ) is a historical region of Western Asia situated within the Tigris–Euphrates river system, in the northern part of the F ...

ns and Ancient Egyptians had vine plantations and winemaking skills. Greek philosophers praised the healing powers of grapes both whole and in the form of wine. ''Vitis vinifera'' cultivation and

winemaking Winemaking or vinification is the production of wine, starting with the selection of the fruit, its fermentation into alcohol, and the bottling of the finished liquid. The history of wine-making stretches over millennia. The science of wine and ...

began during the

Han Dynasty The Han dynasty (, ; ) was an imperial dynasty of China (202 BC – 9 AD, 25–220 AD), established by Liu Bang (Emperor Gao) and ruled by the House of Liu. The dynasty was preceded by the short-lived Qin dynasty (221–207 BC) and a warr ...

in the 2nd century with the importation of the species from Ta-Yuan. However, wild vine "mountain grapes" like ''

Vitis thunbergii ''Vitis ficifolia'' is a species of liana in the grape family native to the Asian temperate climate zone. It is found in mainland China (Hebei, Henan, Jiangsu, Shaanxi, Shandong and Shanxi provinces), Japan (prefectures of Hokkaido, Honshu, ...

'' were being used for wine making before that time. In

traditional medicine Traditional medicine (also known as indigenous medicine or folk medicine) comprises medical aspects of traditional knowledge that developed over generations within the folk beliefs of various societies, including indigenous peoples, before the ...

of India ''V. vinifera'' is used in prescriptions for cough, respiratory tract

catarrh Catarrh is an exudate of inflamed mucous membranes in one of the airways or cavities of the body, usually with reference to the throat and paranasal sinuses. It can result in a thick exudate of mucus and white blood cells caused by the swelling o ...

, subacute cases of enlarged liver and spleen, as well as in alcohol-based tonics (Aasavs). In the Mediterranean Basin, leaves and young stems are traditionally used to feed sheep and goats after grapevine pruning. Using the sap of grapevines, European folk healers sought to cure skin and eye diseases. Other historical uses include the

being used to stop bleeding, pain and inflammation of

hemorrhoids Hemorrhoids (or haemorrhoids), also known as piles, are vascular structures in the anal canal. In their normal state, they are cushions that help with stool control. They become a disease when swollen or inflamed; the unqualified term ''hemo ...

. Unripe grapes were used for treating sore throats, and raisins were given as treatments for consumption (

tuberculosis Tuberculosis (TB) is an infectious disease usually caused by '' Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in ...

constipation Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement ...

and

thirst Thirst is the craving for potable fluids, resulting in the basic instinct of animals to drink. It is an essential mechanism involved in fluid balance. It arises from a lack of fluids or an increase in the concentration of certain osmolites, suc ...

. Ripe grapes were used for the treatment of

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

cholera Cholera is an infection of the small intestine by some strains of the bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea that lasts a few days. Vomiting and ...

smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus) which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) c ...

nausea Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. While not painful, it can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the ...

, skin and eye infections as well as

kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...

and liver diseases. Seedless grape varieties were developed to appeal to consumers, but researchers are now discovering that many of the healthful properties of grapes may actually come from the seeds themselves, thanks to their enriched

phytochemical Phytochemicals are chemical compounds produced by plants, generally to help them resist fungi, bacteria and plant virus infections, and also consumption by insects and other animals. The name comes . Some phytochemicals have been used as poisons ...

content. Grapevine leaves are filled with minced meat (such as lamb, pork or beef), rice and onions in the making of Balkan traditional

dolma Dolma (Turkish for “stuffed”) is a family of stuffed dishes associated with Ottoman cuisine, and common in modern national cuisines of regions and countries that once were part of the Ottoman Empire. Some types of dolma are made with whol ...

. A popular cultivar in Australia, ''

Vitis 'Ornamental Grape' ''Vitis'' 'Ornamental Grape', also known as ornamental grapevine, Ganzin glory, glory vine and crimson glory, is a nonfruiting ornamental plant that is a hybrid of ''Vitis vinifera'' (Aramon noir) and ''Vitis rupestris'' (Alicante Ganzin).Ganzin, ...

'', derived from Vitis vinifera x

Vitis rupestris ''Vitis rupestris'' is a species of grape native to the United States that is known by many common names including July, Coon, sand, sugar, beach, bush, currant, ingar, rock, and mountain grape. It is used for breeding several French-American hy ...

, is used in gardens for its impressive foliage that turn brilliant red, scarlet, purple and/or orange in autumn. Originally bred in France, it thrives in a range of climates from hot and dry, to cool moist and subtropical, with different soil types benefitting the plant.

Chemistry

Phenolics

''V. vinifera'' contains many phenolic compounds.

Anthocyanin Anthocyanins (), also called anthocyans, are water-soluble vacuolar pigments that, depending on their pH, may appear red, purple, blue, or black. In 1835, the German pharmacist Ludwig Clamor Marquart gave the name Anthokyan to a chemical compo ...

s can be found in the skin of the berries, hydroxycinnamic acids in the pulp and condensed tannins of the proanthocyanidins type in the seeds. Stilbenoids can be found in the skin and in wood.

Stilbenoids

''Trans''-

resveratrol Resveratrol (3,5,4′-trihydroxy-''trans''-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens, such as bacteria or fungi. Sources ...

is a phytoalexin produced against the growth of fungal pathogens such as ''

Botrytis cinerea ''Botrytis cinerea'' is a necrotrophic fungus that affects many plant species, although its most notable hosts may be wine grapes. In viticulture, it is commonly known as "botrytis bunch rot"; in horticulture, it is usually called "grey mould" or ...

'' and

delta-viniferin δ-Viniferin is a resveratrol dehydrodimer. It is an isomer of epsilon-viniferin. It can be isolated from stressed grapevine (''Vitis vinifera'') leaves. It is also found in plant cell cultures and wine. It can also be found in ''Rheum maximowicz ...

is another grapevine phytoalexin produced following

fungal infection Fungal infection, also known as mycosis, is disease caused by fungi. Different types are traditionally divided according to the part of the body affected; superficial, subcutaneous, and systemic. Superficial fungal infections include common ti ...

by '' Plasmopara viticola''. * Astringin

Anthocyanins

''Vitis vinifera'' red cultivars are rich in

anthocyanin Anthocyanins (), also called anthocyans, are water-soluble vacuolar pigments that, depending on their pH, may appear red, purple, blue, or black. In 1835, the German pharmacist Ludwig Clamor Marquart gave the name Anthokyan to a chemical compo ...

s that impart their colour to the berries (generally in the skin). The 5 most basic anthocyanins found in grape are: *

Cyanidin-3-O-glucoside Chrysanthemin is an anthocyanin. It is the 3- glucoside of cyanidin. Natural occurrences Chrysanthemin can be found in the roselle plant (''Hibiscus sabdariffa'', Malvaceae), different Japanese angiosperms, ''Rhaponticum'' (Asteraceae), The ...

Delphinidin-3-O-glucoside Myrtillin is an anthocyanin. It is the 3- glucoside of delphinidin. It can be found in all green plants, most abundantly in blackcurrant, blueberry, huckleberry, bilberry leaves and in various myrtles, roselle plants, and ''Centella asiatica' ...

* Malvidin-3-O-glucoside *

Petunidin-3-O-glucoside Petunidin-3-''O''-glucoside is anthocyanin. It is found in fruits and berries, in red ''Vitis vinifera'' grapes and red wine.Peonidin-3-O-glucoside Peonidin-3-''O''-glucoside is anthocyanin. It is found in fruits and berries, in red ''Vitis vinifera'' grapes and red wine, in red onions and in purple corn.Anthocyanins isolated from purple corn (''Zea mays'' L.). Hiromitsu Aoki, Noriko Kuze and ...

Cultivars like Graciano may also contain : ; acetylated anthocyanins * Cyanidin-3-(6-acetyl)-glucoside * Delphinidin-3-(6-acetyl)-glucoside * Malvidin-3-(6-acetyl)-glucoside * Petunidin-3-(6-acetyl)-glucoside * Peonidin-3-(6-acetyl)-glucoside ; coumaroylated anthocyanins * Cyanidin-3-(6-p-coumaroyl)-glucoside *

Delphinidin-3-(6-p-coumaroyl)-glucoside Delphinidin 3-''O''-(6-''p''-coumaroyl)glucoside is a ''p''-coumaroylated anthocyanin. It can be found in some red ''Vitis vinifera'' grape cultivars (like Graciano) and in red wine. It is formed by the enzyme anthocyanin 3-''O''-glucoside 6� ...

* Malvidin-3-(6-p-coumaroyl)-glucoside cis * Malvidin-3-(6-p-coumaroyl)-glucoside trans * Petunidin-3-(6-p-coumaroyl)-glucoside * Peonidin-3-(6-p-coumaroyl)-glucoside ; caffeoylated anthocyanins * Malvidin-3-(6-p-caffeoyl)-glucoside * Peonidin-3-(6-p-caffeoyl)-glucoside

Other chemicals

Isoprenoid monoterpenes are present in grape, above all acyclic

linalool Linalool () refers to two enantiomers of a naturally occurring terpene alcohol found in many flowers and spice plants. Linalool has multiple commercial applications, the majority of which are based on its pleasant scent (floral, with a touch of ...

geraniol Geraniol is a monoterpenoid and an alcohol. It is the primary component of citronella oil and is a primary component of rose oil, palmarosa oil. It is a colorless oil, although commercial samples can appear yellow. It has low solubility in water ...

, nerol, citronellol, homotrienol and monocyclic α-

terpineol Terpineol is any of four isomeric monoterpenoids. Terpenoids are terpene that are modified by the addition of a functional group, in this case, an alcohol. Terpineols have been isolated from a variety of sources such as cardamom, cajuput oil, p ...

, mostly occurring as glycosides. Carotenoids accumulate in ripening grape berries. Oxidation of carotenoids produces volatile fragments, C13-

norisoprenoid Terpenes () are a class of natural products consisting of compounds with the formula (C5H8)n for n > 1. Comprising more than 30,000 compounds, these unsaturated hydrocarbons are produced predominantly by plants, particularly conifers. Terpenes ...

s. These are strongly odoriferous compounds, such as β- ionone (aroma of viola),

damascenone Damascenones are a series of closely related chemical compounds that are components of a variety of essential oils. The damascenones belong to a family of chemicals known as rose ketones, which also includes damascones and ionones. ''beta''-Dam ...

(aroma of exotic fruits), β-

damascone Damascones are a series of closely related chemical compounds that are components of a variety of essential oils. The damascones belong to a family of chemicals known as rose ketones, which also includes damascenones and ionones. ''beta''-Damas ...

(aroma of rose) and β- ionol (aroma of flowers and fruits).

Melatonin Melatonin is a natural product found in plants and animals. It is primarily known in animals as a hormone released by the pineal gland in the brain at night, and has long been associated with control of the sleep–wake cycle. In vertebrates ...

, an alkaloid, has been identified in grape. In addition, seeds are rich in

unsaturated fatty acids In nutrition science, nutrition, biology, and chemistry, fat usually means any ester of fatty acids, or a mixture of such chemical compound, compounds, most commonly those that occur in living beings or in food. The term often refers spec ...

, which helps lowering levels of total

cholesterol Cholesterol is any of a class of certain organic molecules called lipids. It is a sterol (or modified steroid), a type of lipid. Cholesterol is biosynthesized by all animal cells and is an essential structural component of animal cell mem ...

and

LDL Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. These groups, from least dense to most dense, are chylomicrons (aka ULDL by the overall densit ...

cholesterol in the blood.

History

Prehistory

Antiquity

Medieval era

Early modern period

Contemporary period

Description

Inflorescences

Distribution

Cultivation

Chemistry

Phenolics

Stilbenoids

Anthocyanins

Other chemicals

See also

References

Further reading