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Visine is a brand of
eye drop Eye drops or eyedrops are liquid drops applied directly to the surface of the eye usually in small amounts such as a single drop or a few drops. Eye drops usually contain saline to match the salinity of the eye. Drops containing only saline ...
s produced by Johnson & Johnson. Johnson & Johnson acquired Visine, along with
Pfizer Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer ...
's entire consumer healthcare portfolio, in December 2006. In some countries it is called Vispring.


Visine Original

The active ingredients in the original Visine formulation are potassium chloride and tetrahydrozoline hydrochloride which is a
vasoconstrictor Vasoconstriction is the narrowing of the blood vessels resulting from contraction of the muscular wall of the vessels, in particular the large arteries and small arterioles. The process is the opposite of vasodilation, the widening of blood vess ...
, and therefore constricts the eye's superficial blood vessels.


Administration

Visine is administered topically with 1 to 2 drops applied to the affected eye(s) up to 4 times daily.


Adverse effects

*Those using Visine Original frequently report stinging and burning upon application. *Use of this product can cause a rebound effect causing the redness to worsen. Prolonged use can cause blood vessels to be dilated for an extended period of time. Use should be limited unless specified by a doctor. *A red eye may often be indicative of more serious underlying ocular condition; simply reducing blood flow to the area won't solve the condition and may even exacerbate symptoms. *These drops are also not advised for contact lens wearers because decreased blood flow to the surface of the eye will further lower the levels of oxygen available to the eye. *Visine is not to be used by patients with
glaucoma Glaucoma is a group of eye diseases that result in damage to the optic nerve (or retina) and cause vision loss. The most common type is open-angle (wide angle, chronic simple) glaucoma, in which the drainage angle for fluid within the eye rem ...
since the production of more liquids only contributes to the problem of high pressure within the eye.


Side effects

A common
urban legend An urban legend (sometimes contemporary legend, modern legend, urban myth, or urban tale) is a genre of folklore comprising stories or fallacious claims circulated as true, especially as having happened to a "friend of a friend" or a family m ...
is that a few drops of Visine in an unsuspecting victim's drink will cause harmless but debilitating bouts of explosive diarrhea, akin to that of a
laxative Laxatives, purgatives, or aperients are substances that loosen stools and increase bowel movements. They are used to treat and prevent constipation. Laxatives vary as to how they work and the side effects they may have. Certain stimulant, lubri ...
. This will not produce explosive diarrhea, but oral administration of Visine can induce dangerous side effects related to Visine's ingredient tetrahydrozoline hydrochloride such as: *Dangerously low body temperature (
hypothermia Hypothermia is defined as a body core temperature below in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe ...
) *Blurred vision *
Nausea Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. While not painful, it can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the ...
and
vomiting Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Vomiting can be the result of ailments like food poisoning, gastroenteri ...
(as opposed to explosive diarrhea) *Difficulty in breathing or even a complete halt in breathing *Elevating ( hypertension) then dropping (
hypotension Hypotension is low blood pressure. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Blood pressure is indicated by two numbers, the systolic blood pressure (the top number) and the dia ...
) blood pressure *Possible coma *
Seizures An epileptic seizure, informally known as a seizure, is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain. Outward effects vary from uncontrolled shaking movements involving much of the body with l ...
and tremors *
Death Death is the irreversible cessation of all biological functions that sustain an organism. For organisms with a brain, death can also be defined as the irreversible cessation of functioning of the whole brain, including brainstem, and brain ...
Anyone ingesting Visine should get medical attention or contact a
poison control center A poison control center is a medical service that is able to provide immediate, free, and expert treatment advice and assistance over the telephone in case of exposure to poisonous or hazardous substances. Poison control centers answer questions ...
immediately. Ingesting Visine was shown to be lethal in the case of Lana Clayton, who killed her husband by administering Visine to his drinks over a period of three days in July 2018.


Varieties

Visine is formulated in several varieties: VISINE A.C. - Astringent/Redness Reliever Eye Drops (Tetrahydrozoline HCl 0.05%,
Zinc sulfate Zinc sulfate is an inorganic compound. It is used as a dietary supplement to treat zinc deficiency and to prevent the condition in those at high risk. Side effects of excess supplementation may include abdominal pain, vomiting, headache, and ti ...
0.25%) *Special formula for allergens, such as ragweed, dust, or pollen. VISINE FOR CONTACTS - For Silicone Hydrogel and Hydrophilic lenses *Used primarily for comfort during the day, moistening upon awakening and before sleep. VISINE L.R. (
Oxymetazoline Oxymetazoline, sold under the brand name Afrin among others, is a topical decongestant and vasoconstrictor medication. It is available over-the-counter as a nasal spray to treat nasal congestion and nosebleeds, as eyedrops to treat eye rednes ...
HCI 0.025%) *A longer-lasting formula that lasts for up to 6 hours. VISINE TEARS (
Glycerin Glycerol (), also called glycerine in British English and glycerin in American English, is a simple triol compound. It is a colorless, odorless, viscous liquid that is sweet-tasting and non-toxic. The glycerol backbone is found in lipids known ...
0.2%,
Hypromellose Hypromellose ( INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commerci ...
0.2%,
Polyethylene glycol Polyethylene glycol (PEG; ) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular we ...
400 1% - Used AS NEEDED) * See
artificial tears Artificial tears are lubricating eye drops used to relieve dryness and irritation of the ocular surface. Dry eye syndrome ( keratoconjunctivitis sicca) is a common ocular surface disorder and is characterized by disruption of the tear film and i ...
. VISINE-A (Formerly OCUHIST) ( Naphazoline/pheniramine) *Antihistamine combined with a vasoconstrictor for itchy eyes associated with allergy. VISINE MAXIMUM (
Glycerin Glycerol (), also called glycerine in British English and glycerin in American English, is a simple triol compound. It is a colorless, odorless, viscous liquid that is sweet-tasting and non-toxic. The glycerol backbone is found in lipids known ...
0.2%,
Hypromellose Hypromellose ( INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commerci ...
0.36%, Polyethylene glycol 400 1.0%, Tetrahydrozoline HCI 0.05%) * Includes HYDROBLEND®, which acts as a moisturizer. Lasts up to 10 hours. VISINE TOTALITY (
Glycerin Glycerol (), also called glycerine in British English and glycerin in American English, is a simple triol compound. It is a colorless, odorless, viscous liquid that is sweet-tasting and non-toxic. The glycerol backbone is found in lipids known ...
0.2%,
Hypromellose Hypromellose ( INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commerci ...
0.36%, Polyethylene glycol 400 1.0%, Tetrahydrozoline HCI 0.05%,
Zinc sulfate Zinc sulfate is an inorganic compound. It is used as a dietary supplement to treat zinc deficiency and to prevent the condition in those at high risk. Side effects of excess supplementation may include abdominal pain, vomiting, headache, and ti ...
0.25%) *Multi-Symptom Relief. Lubricant / Astrigent Redness Reliever Eye Drops (Relief for: red, burning, watery, itchy, gritty, dry, irritated eyes.)


Popular culture

The effect of Visine causing upset gastrointestinal effects when being ingested is depicted in the movie ''
Wedding Crashers ''Wedding Crashers'' is a 2005 American comedy film directed by David Dobkin, written by Steve Faber and Bob Fisher, starring Owen Wilson, Vince Vaughn and Christopher Walken with Rachel McAdams, Isla Fisher, Bradley Cooper and Jane Seymou ...
,'' where John Beckwith (portrayed by
Owen Wilson Owen Cunningham Wilson (born November 18, 1968) is an American actor. He has had a long association with filmmaker Wes Anderson with whom he shared writing and acting credits for '' Bottle Rocket'' (1996), '' Rushmore'' (1998), and '' The Royal ...
) poisons Sack's (
Bradley Cooper Bradley Charles Cooper (born January 5, 1975) is an American actor and filmmaker. He is the recipient of various accolades, including a British Academy Film Award and two Grammy Awards, in addition to nominations for nine Academy Awards, si ...
) drink, causing him to suffer all night. John Beckwith also uses the Visine several times over the course of the film to fake crying. This movie has gained notoriety for encouraging the deadly prank of putting Visine eyedrops in drinking water bottles, threatening severe or fatal injury to drinkers. The
urban legend An urban legend (sometimes contemporary legend, modern legend, urban myth, or urban tale) is a genre of folklore comprising stories or fallacious claims circulated as true, especially as having happened to a "friend of a friend" or a family m ...
about Visine's explosive diarrhea-inducing capacity is also perpetuated in the movie version of ''
I Hope They Serve Beer in Hell ''I Hope They Serve Beer in Hell'' is a book of autobiographical short stories about sex and drinking adventures written by Tucker Max. It was a ''New York Times'' #1 bestseller and made the Best Seller List each year from 2006 to 2011. It has ...
''. In the movie, the main character
Tucker Max Tucker Max (born September 27, 1975) is an American author and public speaker. He chronicles his drinking and sexual encounters in the form of short stories on his website ''TuckerMax.com'', which has received millions of visitors since Max lau ...
(played by
Matt Czuchry Matthew Charles Czuchry (; born May 20, 1977) is an American actor. He is known for his roles as Logan Huntzberger on The WB television series ''Gilmore Girls'' (2005–2007) and Cary Agos on the CBS television drama ''The Good Wife'' (2009–2 ...
), is making fun of two women at the bar, in which one of them squirts Visine into his beer bottle. This leads to Tucker and an allegedly married woman he leaves the bar with to both have extreme explosive diarrhea. In season 4, episode 3 of ''Orange Is the New Black'', an inmate poisons a fellow inmate using Visine; the poisoned inmate immediately experiences explosive diarrhea. In season 3, episode 19 of Glee visine is referenced as being used as an ingredient in ‘Prom Punch’ by Sue Sylvester.


References


External links


Visine webpageSnopes reference
{{Johnson & Johnson Ophthalmology drugs Johnson & Johnson brands