Visceral gout is a disease of birds in which

kidney failure Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney failure is classified as eit ...

causes a build-up of

urate Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of ...

s in the internal organs, leaving a chalky white coating on them. Symptoms include

anorexia Anorexia nervosa, often referred to simply as anorexia, is an eating disorder characterized by low weight, food restriction, body image disturbance, fear of gaining weight, and an overpowering desire to be thin. ''Anorexia'' is a term of Gre ...

and emaciation. It is a problem common to caged birds. Vultures are particularly sensitive to poisoning by

diclofenac Diclofenac, sold under the brand name Voltaren, among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout. It is taken by mouth or rectally in a suppository, used by injection, or ...

, which leads to kidney failure, visceral gout, and death.

Threat to vultures

The collapse of the

vulture A vulture is a bird of prey that scavenges on carrion. There are 23 extant species of vulture (including Condors). Old World vultures include 16 living species native to Europe, Africa, and Asia; New World vultures are restricted to North and ...

population in

India India, officially the Republic of India (Hindi: ), is a country in South Asia. It is the seventh-largest country by area, the second-most populous country, and the most populous democracy in the world. Bounded by the Indian Ocean on the so ...

and

Pakistan Pakistan ( ur, ), officially the Islamic Republic of Pakistan ( ur, , label=none), is a country in South Asia. It is the world's fifth-most populous country, with a population of almost 243 million people, and has the world's second-lar ...

, to about a twentieth of their original numbers, has been caused by

, which is a non-steroidal anti-inflammatory drug (

NSAID Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of ...

). Diclofenac is given to working and ill farm cattle to reduce pain so that they can work on the land for longer. Farmers leave dead farm animals out in the open for the vultures to tidy up, and the vultures then feed from the carcasses of the cattle that die, and are poisoned by the diclofenac contained in the flesh they eat. Vultures are now not present in large enough numbers to tidy up all the dead animals. Instead, dead animals are now likely to rot in the open and be partly eaten by rats or wild dogs or other pests, causing major concern and human health hazards including risks of

rabies Rabies is a viral disease that causes encephalitis in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: nausea, vomiting, ...

Meloxicam Meloxicam, sold under the brand name Mobic among others, is a nonsteroidal anti-inflammatory medication (NSAID) used to treat pain and inflammation in rheumatic diseases and osteoarthritis. It is used by mouth or by injection into a vein. It i ...

(another NSAID) has been found to be harmless to vultures and should prove an acceptable alternative to diclofenac. The Government of India has banned diclofenac, but it continues to be sold over a year later and is still a problem in other parts of the World.

References

Visceral gout in caged birds
*"India's Vultures Fall Prey to a Drug in the Cattle They Feed On", New York Times, Amelia Gentleman, March 28, 2006.
NSAID effects on vultures (BBC website)
Bird diseases