Viridicatumtoxin A (also simply called viridicatumtoxin) is a
fungus-derived
tetracycline-like
antibiotic
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of ...
, whose chemical structure was determined in 1976.
It is found in ''
Penicillium viridicatum
''Penicillium viridicatum'' is a psychrophilic species of fungus in the genus , penicillic acid
Penicillic acid is a mycotoxin that is produced by ''Aspergillus flavus'' and ''Penicillium roqueforti'' mold. It is also the major product of acid ...
'',
''
Penicillium aethiopicum
''Penicillium aethiopicum'' is a fungus species of the genus of '' Penicillium''. ''Penicillium aethiopicum'' produces viridicatumtoxin
Viridicatumtoxin A (also simply called viridicatumtoxin) is a fungus-derived tetracycline-like antibiot ...
'',
among other fungi.
Like
viridicatumtoxin B
Viridicatumtoxin B is a fungus-derived tetracycline-like antibiotic discovered in 2008. It was isolated from small amounts of penicillium fungi. A synthetic structure matching that of natural viridicatumtoxin B makes possible synthetic variants ...
, viridicatumtoxin A inhibits growth of ''
Staphylococcus aureus
''Staphylococcus aureus'' is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. It is often positive ...
'', including
methicillin resistant ''S. aureus'' and
quinolone
Quinolone may refer to:
* 2-Quinolone
* 4-Quinolone
* Quinolone antibiotic
A quinolone antibiotic is a member of a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone. They ...
-resistant ''S. aureus'', with an activity 8 to 64 times greater than that of tetracycline.
References
Tetracycline antibiotics
Cyclohexenes
Spiro compounds
{{antibiotic-stub