Vesicle-associated membrane protein 8 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''VAMP8''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. It is associated with the perinuclear vesicular structures of the early endocytic compartment. It has been found that VAMP8 interacts specifically with the soluble NSF-attachment protein (alpha-SNAP), most likely through an VAMP8-containing SNARE complex.
Phosphorylation of VAMP8 inside the conserved SNARE-domain can suppress vesicle fusion.
Interactions
Vesicle-associated membrane protein 8 has been shown to
interact
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with
STX4
Syntaxin-4 is a protein that in humans is encoded by the ''STX4'' gene.
Interactions
STX4 has been shown to interact with:
* Gelsolin,
* NAPA,
* RAB4A,
* SNAP-25,
* SNAP23,
* STXBP1,
* STXBP5,
* Syntaxin binding protein 3,
* TXLNB,
...
,
SNAP23
Synaptosomal-associated protein 23 is a protein that in humans is encoded by the ''SNAP23'' gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Function
Specificity of vesicular tran ...
,
STX1A
Syntaxin-1A is a protein that in humans is encoded by the ''STX1A'' gene.
Function
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the local ...
,STX8
Syntaxin-8 is a protein that in humans is encoded by the ''STX8'' gene.
Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobre ...
STX7
Syntaxin-7 is a protein that in humans is encoded by the ''STX7'' gene.
In melanocytic cells STX7 gene expression may be regulated by MITF.
Interactions
STX7 has been shown to interact with STX8, VPS18, Vesicle-associated membrane protein 8 ...
.
References
Further reading
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{{PDB Gallery, geneid=8673