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Vasoplegic syndrome (VPS) is a
There is some evidence to support the use of methylene blue in the treatment of this condition.
postperfusion syndrome
Postperfusion syndrome, also known as "pumphead", is a constellation of neurocognitive impairments attributed to cardiopulmonary bypass (CPB) during cardiac surgery. Symptoms of postperfusion syndrome are subtle and include defects associated wit ...
characterized by low systemic vascular resistance
Vascular resistance is the resistance that must be overcome to push blood through the circulatory system and create flow. The resistance offered by the systemic circulation is known as the systemic vascular resistance (SVR) or may sometimes be cal ...
and a high cardiac output.
Causes
VPS occurs more frequently after on pump CABG surgery versus off pump CABG surgery.Hypothermia
Hypothermia is defined as a body core temperature below in humans. Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. In severe ...
during surgery may also increase ones risk of developing VPS post operatively.Diagnosis
Definition
Vasoplegic syndrome is defined as low systemicvascular resistance
Vascular resistance is the resistance that must be overcome to push blood through the circulatory system and create flow. The resistance offered by the systemic circulation is known as the systemic vascular resistance (SVR) or may sometimes be cal ...
(SVR index <1,600 dyn∙sec/cm5/m2) and high cardiac output (cardiac index >2.5 L/min/m2) within the first 4 postoperative hours.
Treatment
There is some evidence to support the use of methylene blue in the treatment of this condition.
Epidemiology
One case series reports a rate of 1 in 120 cases.References
{{Medicine, state=collapsed Cardiac surgery Syndromes