Vacuolar segregation protein 7 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in yeast is encoded by the ''VAC7''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
. VAC7 is a component of the PI(3,5)P2 regulatory complex, composed of
ATG18,
FIG4,
FAB1,
VAC14 and VAC7.
Function
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of
phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). VAC7 activates
FAB1 kinase for example during
hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of
VAC14 and
FIG4. VAC7 is directly involved in
vacuolar
A vacuole () is a membrane-bound organelle which is present in plant and fungal cells and some protist, animal, and bacterial cells. Vacuoles are essentially enclosed compartments which are filled with water containing inorganic and organic mo ...
membrane scission and is required for normal vacuole acidification, inheritance and morphology.
UniProt
UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects. It contains a large amount of information about the biological function of proteins derived from ...
References
Saccharomyces cerevisiae genes
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