VIS1 (viral integration site 1), also known as HIS-1, is a
long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of
myeloid leukemia. In
murine myeloid leukemias, this gene is a common site of viral insertion by the murine
ecotropic retrovirus CasBrM
It is conserved amongst
vertebrates, including human, mice, cats, pigs, cattle and dogs.
Expression of VIS1 is restricted to
epithelial cells,
leukemias and
carcinomas.
See also
*
Long noncoding RNA
References
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Non-coding RNA