Vesicle-associated membrane protein 3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''VAMP3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
Interactions
VAMP3 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
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BCAP31
B-cell receptor-associated protein 31 is a protein that in humans is encoded by the ''BCAP31'' gene.
Interactions
BCAP31 has been shown to interact with:
* APP,
* BCL2L1,
* BCL2,
* CASP8, and
* VAMP3
Vesicle-associated membrane protein 3 ...
,
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BVES,
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SNAP23
Synaptosomal-associated protein 23 is a protein that in humans is encoded by the ''SNAP23'' gene. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Function
Specificity of vesicular tran ...
,
STX4
Syntaxin-4 is a protein that in humans is encoded by the ''STX4'' gene.
Interactions
STX4 has been shown to interact with:
* Gelsolin,
* NAPA,
* RAB4A,
* SNAP-25,
* SNAP23,
* STXBP1,
* STXBP5,
* Syntaxin binding protein 3,
* TXLNB,
...
,STX6
Syntaxin-6 is a protein that in humans is encoded by the ''STX6'' gene.
Interactions
STX6 has been shown to interact with SNAP23, VAMP3 and VAMP4.
N terminal protein domain
The protein domain Syntaxin 6 N terminal protein domain is a solubl ...
.
References
Further reading
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{{Vesicular transport proteins