Uroporphyrinogen-III C-methyltransferase (), ''uroporphyrinogen methyltransferase'', ''uroporphyrinogen-III methyltransferase'', ''adenosylmethionine-uroporphyrinogen III methyltransferase'', ''S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase'', ''uroporphyrinogen-III methylase'', ''SirA'', ''CysG'', ''CobA'', ''uroporphyrin-III C-methyltransferase'', ''S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase'') is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...
with
systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature.
A semisystematic name or semitrivial ...
''S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase''.
This enzyme
catalyses the following
chemical reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the pos ...
: 2
S-adenosyl-L-methionine
''S''-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur through ...
+ uroporphyrinogen III
2 S-adenosyl-L-homocysteine + precorrin-2 (overall reaction)
:(1a) S-adenosyl-L-methionine + uroporphyrinogen III
S-adenosyl-L-homocysteine + precorrin-1
:(1b) S-adenosyl-L-methionine + precorrin-1
S-adenosyl-L-homocysteine + precorrin-2
Uroporphyrinogen-III C-methyltransferase catalyses two
methylation reactions. The first reaction converts
uroporphyrinogen III
Uroporphyrinogen III is a tetrapyrrole, the first macrocyclic intermediate in the biosynthesis of heme, chlorophyll, vitamin B12, and siroheme. It is a colorless compound, like other porphyrinogens.
Structure
The molecular structure of uroporphy ...
into precorrin-1. The second converts precorrin-1 into precorrin-2. These reactions are part of the biosynthetic pathway to
cobalamin
Vitamin B12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, in both fatty acid and amino acid metabolism. ...
(vitamin B
12) in both
anaerobic
Anaerobic means "living, active, occurring, or existing in the absence of free oxygen", as opposed to aerobic which means "living, active, or occurring only in the presence of oxygen." Anaerobic may also refer to:
* Anaerobic adhesive, a bonding a ...
and
aerobic
Aerobic means "requiring air," in which "air" usually means oxygen.
Aerobic may also refer to
* Aerobic exercise, prolonged exercise of moderate intensity
* Aerobics, a form of aerobic exercise
* Aerobic respiration, the aerobic process of cel ...
bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of prokaryotic microorganisms. Typically a few micrometr ...
.
See also
*
Cobalamin biosynthesis
Cobalamin biosynthesis is the process by which bacteria and archea make cobalamin, vitamin B12. Many steps are involved in converting aminolevulinic acid via uroporphyrinogen III and adenosylcobyric acid to the final forms in which it is used by ...
References
External links
*
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