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Melange (), often referred to as "the spice", is the fictional
psychedelic drug Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science o ...
central to the ''Dune'' series of
science fiction Science fiction (sometimes shortened to Sci-Fi or SF) is a genre of speculative fiction which typically deals with imaginative and futuristic concepts such as advanced science and technology, space exploration, time travel, parallel unive ...
novels by
Frank Herbert Franklin Patrick Herbert Jr. (October 8, 1920February 11, 1986) was an American science fiction author best known for the 1965 novel '' Dune'' and its five sequels. Though he became famous for his novels, he also wrote short stories and worked a ...
and derivative works. In the series, the most essential and valuable commodity in the universe is melange, a drug that gives the user a longer life span, greater vitality, and heightened awareness. In some humans, the spice can also unlock prescience, a form of
precognition Precognition (from the Latin 'before', and 'acquiring knowledge') is the purported psychic phenomenon of seeing, or otherwise becoming directly aware of, events in the future. There is no accepted scientific evidence that precognition is a ...
based in genetics but made possible by use of the drug in larger dosages. Among other functions, prescience makes safe and accurate interstellar travel possible. However, melange is also highly addictive, and withdrawal is fatal. Harvesting melange is also hazardous in the extreme, as its only known source is the harsh
desert planet A desert planet, also known as a dry planet, an arid planet, or a dune planet, is a theoretical type of terrestrial planet with a surface consistency similar to Earth's hot desert A desert is a barren area of landscape where little precipit ...
Arrakis Arrakis ()—informally known as Dune and later called Rakis—is a fictional desert planet featured in the Dune (franchise), ''Dune'' series of novels by Frank Herbert. Herbert's first novel in the series, 1965's ''Dune (novel), Dune'', is consi ...
, and melange deposits are guarded by giant sandworms.


Description


Properties

Melange is a drug that prolongs life and bestows heightened vitality and awareness, and in some humans unlocks prescience, a form of precognition based in genetics but made possible by use of the spice. In the story, the
Spacing Guild The Spacing Guild is an organization in Frank Herbert's science fiction ''Dune'' universe which possesses a monopoly on interstellar travel and banking. Guild Navigators (alternately Guildsmen or Steersmen) use the drug melange (also called "the ...
uses humans mutated by excessive consumption of melange, and thereby bestowed with limited prescience, to safely navigate
heighliner Technology is a key aspect of the fictional setting of the '' Dune series'' of science fiction novels written by Frank Herbert, and derivative works. Herbert's concepts and inventions have been analyzed and deconstructed in at least one book, ''T ...
starship A starship, starcraft, or interstellar spacecraft is a theoretical spacecraft designed for interstellar travel, traveling between planetary systems. The term is mostly found in science fiction. Reference to a "star-ship" appears as early as 188 ...
s through
folded space Technology is a key aspect of the fictional setting of the ''Dune (franchise), Dune series'' of science fiction novels written by Frank Herbert, and derivative works. Herbert's concepts and inventions have been analyzed and deconstructed in at lea ...
. In larger quantities, the spice possesses intense
psychotropic A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. Th ...
effects and is used as a powerful
entheogen Entheogens are psychoactive substances that induce alterations in perception, mood (psychology), mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclop ...
by both the
Bene Gesserit The Bene Gesserit () refers to a key social, religious, and political force in Frank Herbert's fictional ''Dune'' universe. The group is an exclusive sisterhood whose members train their bodies and minds through years of physical and mental ...
and the
Fremen The Fremen are a group of people in the fictional ''Dune'' universe created by Frank Herbert. First appearing in the 1965 novel ''Dune'', the Fremen inhabit the desert planet Arrakis (also known as Dune), which is the sole known source in the ...
people of
Arrakis Arrakis ()—informally known as Dune and later called Rakis—is a fictional desert planet featured in the Dune (franchise), ''Dune'' series of novels by Frank Herbert. Herbert's first novel in the series, 1965's ''Dune (novel), Dune'', is consi ...
to initiate
clairvoyant Clairvoyance (; ) is the magical ability to gain information about an object, person, location, or physical event through extrasensory perception. Any person who is claimed to have such ability is said to be a clairvoyant () ("one who sees cl ...
and
precognitive Precognition (from the Latin 'before', and 'acquiring knowledge') is the purported psychic phenomenon of seeing, or otherwise becoming directly aware of, events in the future. There is no accepted scientific evidence that precognition is a ...
trances, access genetic memory, and heighten other abilities. The Fremen also use the spice to make, among other things, paper, plastics, and chemical explosives, and the existence of "spice-cloth" and "spice-fiber" rugs are noted in ''
Dune Messiah ''Dune Messiah'' is a science fiction novel by American writer Frank Herbert, the second in his ''Dune'' series of six novels. A sequel to ''Dune'' (1965), it was originally serialized in ''Galaxy'' magazine in 1969, and then published by Putnam ...
'' (1969) and ''
Children of Dune ''Children of Dune'' is a 1976 science fiction novel by Frank Herbert, the third in his ''Dune'' series of six novels. It was originally serialized in '' Analog Science Fiction and Fact'' in 1976, and was the last ''Dune'' novel to be seriali ...
'' (1976). Melange can be mixed with food, and it is used to make beverages such as spice coffee, spice beer, and spice liquor. By the events of ''Dune'', the spice is used all over the universe and is a sign of wealth. Duke Leto Atreides notes that of every valuable commodity known to mankind, "all fades before melange. A handful of spice will buy a home on Tupile." Jon Michaud of ''
The New Yorker ''The New Yorker'' is an American weekly magazine featuring journalism, commentary, criticism, essays, fiction, satire, cartoons, and poetry. Founded as a weekly in 1925, the magazine is published 47 times annually, with five of these issues ...
'' wrote: "Imagine a substance with the combined worldwide value of cocaine and petroleum and you will have some idea of the power of melange." Due to the rarity and value of melange and its necessity as a catalyst for interstellar travel, the
Padishah Emperor Multiple organizations of the ''Dune'' universe dominate the political, religious, and social arena of the setting of Frank Herbert's ''Dune'' series of science fiction novels, and derivative works. Set tens of thousands of years in the future, ...
's power at the outset of ''Dune'' is secured by his control of Arrakis, which puts him on equal footing with both the assembly of noble families called the
Landsraad Multiple organizations of the ''Dune'' universe dominate the political, religious, and social arena of the setting of Frank Herbert's Dune (franchise), ''Dune'' series of science fiction novels, and derivative works. Set tens of thousands of year ...
and the Spacing Guild, which monopolizes interstellar travel. Seizing control of the planet,
Paul Atreides Paul Atreides (; later known as Paul Muad'Dib, and later still as The Preacher) is a fictional character in the ''Dune'' universe created by Frank Herbert. Paul is the primary protagonist in the first two novels in the series, ''Dune'' (1965) ...
intensifies this form of
hydraulic despotism A hydraulic empire, also known as a hydraulic despotism, hydraulic society, hydraulic civilization, or water monopoly empire, is a social or government structure which maintains power and control through exclusive control over right to water, acc ...
by asserting control over both the Landsraad and Spacing Guild, as well as other factions in the universe. Paul's sister
Alia Alia or ALIA may refer to: People *Alia (name), a list of people with the surname or given name Places *Alia, Sicily, Italy, a comune * Alia (Phrygia), a town of ancient Phrygia which remains a Roman Catholic titular bishopric *Alía, Spain, a mu ...
says in ''Children of Dune'', "The spice often called 'the secret coinage'. Without melange, the Spacing Guild's heighliners could not move ... Without melange and its amplification of the human immunogenic system, life expectancy for the very rich degenerated by a factor of at least four. Even the vast middle class of the Imperium ate diluted melange in small sprinklings with at least one meal a day."


Physiological side effects

Extensive use of the drug tints the
sclera The sclera, also known as the white of the eye or, in older literature, as the tunica albuginea oculi, is the opaque, fibrous, protective, outer layer of the human eye containing mainly collagen and some crucial elastic fiber. In humans, and som ...
,
cornea The cornea is the transparent front part of the eye that covers the iris, pupil, and anterior chamber. Along with the anterior chamber and lens, the cornea refracts light, accounting for approximately two-thirds of the eye's total optical power ...
, and
iris Iris most often refers to: *Iris (anatomy), part of the eye *Iris (mythology), a Greek goddess * ''Iris'' (plant), a genus of flowering plants *Iris (color), an ambiguous color term Iris or IRIS may also refer to: Arts and media Fictional enti ...
of the user to a dark shade of blue, called "blue-in-blue" or "the Eyes of Ibad", which is something of a source of pride among the Fremen and a symbol of their tribal bond. In ''Dune'', Paul initially has green eyes, but after several years on Arrakis they begin to take on the deep, uniform blue of the Fremen. On other planets, the addicted often use tinted
contact lens Contact lenses, or simply contacts, are thin lenses placed directly on the surface of the eyes. Contact lenses are ocular prosthetic devices used by over 150 million people worldwide, and they can be worn to correct vision or for cosmetic ...
es to hide this discoloration. In ''Dune'',
Padishah Emperor Multiple organizations of the ''Dune'' universe dominate the political, religious, and social arena of the setting of Frank Herbert's ''Dune'' series of science fiction novels, and derivative works. Set tens of thousands of years in the future, ...
Shaddam IV Shaddam IV of House Corrino is a fictional character in the ''Dune'' universe created by Frank Herbert. He is Padishah Emperor of the Known Universe in Herbert's 1965 novel ''Dune''. Shaddam's accession to the throne is chronicled in the ''Prel ...
notes of two Guildsmen: Melange is also highly addictive, and withdrawal means certain death.
Paul Atreides Paul Atreides (; later known as Paul Muad'Dib, and later still as The Preacher) is a fictional character in the ''Dune'' universe created by Frank Herbert. Paul is the primary protagonist in the first two novels in the series, ''Dune'' (1965) ...
notes in ''Dune'' that the spice is " poison—so subtle, so insidious... so irreversible. It won't even kill you unless you stop taking it." When aerosolized and used as an
inhalant Inhalants are a broad range of household and industrial chemicals whose volatile vapors or pressurized gases can be concentrated and breathed in via the nose or mouth to produce intoxication, in a manner not intended by the manufacturer. They ...
in extremely high dosages—the standard practice for Guild Navigators—the drug alters the physiology of its user. In the first chapter of ''Dune Messiah'', Guild Navigator Edric is described in his tank of spice gas as "an elongated figure, vaguely humanoid with finned feet and hugely fanned membranous hands—a fish in a strange sea." In ''Children of Dune'', the term "spice trance" is used to describe the effects of an overdose of spice. Alia had previously subjected herself to such an overdose late in ''Dune Messiah'', hoping to enhance her prescient visions. She achieves some success, but in ''Children of Dune'', Leto II and Ghanima blame the trance for Alia's descent into
Abomination Abomination may refer to: *Abomination (Bible), covering Biblical references **Abomination (Judaism) In Judaism, an abomination, horror, or scandal is, in general, an offense against the religious senses of a people, and, in particular, an offen ...
. Fearful of the same fate, they resist Alia's urgings to undergo the spice trance themselves. The trial is later forced upon Leto at Jacurutu when it is suspected that he too is an Abomination. Leto survives the challenge and escapes, but is left changed. Unlike Alia, however, he remains in control, and the spice trance opens his eyes to the Golden Path that will ultimately save humanity.


Appearance

Herbert is vague in describing the appearance of the spice. He hints at its color in ''Dune Messiah'' when he notes that Guild Navigator
Edric Eadric, alternatively spelled Edric or Edrick, is a name of Anglo-Saxon or Jute origin and may refer to: * Eadric of Kent (died c. 686), king of Kent from 685 to 686 * Eadric Streona (died 1017), ealdorman of Mercia under Æthelred II and Cnut * Ea ...
"swam in a container of orange gas ... His tank's vents emitted a pale orange cloud rich with the smell of the geriatric spice, melange." Later in ''
Heretics of Dune ''Heretics of Dune'' is a 1984 science fiction novel by Frank Herbert, the fifth in his ''Dune'' series of six novels. It was ranked as the No. 13 hardcover fiction best seller of 1984 by ''The New York Times''. Fifteen hundred years have pa ...
'' (1984), a discovered hoard of melange appears as "mounds of dark reddish brown". Herbert also indicates
fluorescence Fluorescence is the emission of light by a substance that has absorbed light or other electromagnetic radiation. It is a form of luminescence. In most cases, the emitted light has a longer wavelength, and therefore a lower photon energy, tha ...
in '' God Emperor of Dune'' (1981) when the character
Moneo Moneo, sometimes branded as mon€o, is an electronic purse system available on French bank cards to allow small purchases to be made without cash and used from 1999 to 2015. The system is aimed at small retailers such as bakeries and cafés and ...
notes: "Great bins of melange lay all around in a gigantic room cut from native rock and illuminated by glowglobes ... The spice had glowed radiant blue in the dim silver light. And the smell—bitter cinnamon, unmistakable." Herbert writes repeatedly, starting in ''
Dune A dune is a landform composed of wind- or water-driven sand. It typically takes the form of a mound, ridge, or hill. An area with dunes is called a dune system or a dune complex. A large dune complex is called a dune field, while broad, f ...
'' (1965), that melange smells like cinnamon. In ''Dune'',
Lady Jessica Lady Jessica is a fictional character in the ''Dune'' universe created by Frank Herbert. A main character in the 1965 novel ''Dune'', Jessica also plays an important role in the later installment ''Children of Dune'' (1976). The events surroun ...
notes that her first taste of spice "tasted like cinnamon". Dr. Yueh adds that the flavor is "never twice the same ... It's like life—it presents a different face each time you take it. Some hold that the spice produces a learned-flavor reaction. The body, learning a thing is good for it, interprets the flavor as pleasurable—slightly euphoric. And, like life, never to be truly synthesized."


Sources

In ''Dune'', there is only one source of melange: the sands of the planet Arrakis, colloquially known as Dune, and millennia later called simply "Rakis". Herbert notes in ''Dune'' that a pre-spice mass is "the stage of fungusoid wild growth achieved when water is flooded into the excretions of Little Makers", the "half-plant–half-animal deep-sand vector of the Arrakis sandworm". Gases are produced which result in "a characteristic 'blow', exchanging the material from deep underground for the matter on the surface above it." This blow is explosive in nature, erupting with enough force to kill anyone in the vicinity of it. Frank Herbert describes such a spice blow in the following passage from ''Dune'': Herbert writes that the pre-spice mass, "after exposure to sun and air, becomes melange". He later indicates its color in ''Children of Dune'', when Leto II passes "the leprous blotches of violet sand where a spiceblow had erupted". Collecting the melange is hazardous in the extreme, since rhythmic activity on the desert surface of Arrakis attracts the worms, which can be up to 400 meters (1,300 feet) in length and are capable of swallowing a mining crawler whole. Thus, the mining operation essentially consists of vacuuming it from the surface with a vehicle called a harvester until a worm comes, at which time an aircraft known as a
carryall The term ''carryall'' refers to several types of vehicles, including: historical carriages, automobiles, sleighs, and tractors. Horse-drawn carriage Historically, a carryall was a type of carriage used in the United States in the 19th century. ...
lifts the mining vehicle to safety. The Fremen, who have learned to co-exist with the sandworms in the desert, harvest the spice manually for their own use and for smuggling off-planet. Within the 1500 years between the events of ''God Emperor of Dune'' (1981) and ''Heretics of Dune'' (1984), the
Tleilaxu The Bene Tleilax, also called Tleilaxu , are an extremely xenophobic and isolationist society in Frank Herbert's science fiction ''Dune'' universe. Genetic manipulators who traffic in biological products such as artificial eyes, gholas, and "t ...
discover an artificial method of producing the spice in their
axlotl tank Technology is a key aspect of the fictional setting of the ''Dune (franchise), Dune series'' of science fiction novels written by Frank Herbert, and derivative works. Herbert's concepts and inventions have been analyzed and deconstructed in at lea ...
s, previously used only to create
ghola Technology is a key aspect of the fictional setting of the ''Dune (franchise), Dune series'' of science fiction novels written by Frank Herbert, and derivative works. Herbert's concepts and inventions have been analyzed and deconstructed in at lea ...
s. It is noted in ''Heretics of Dune'' that " r every milligram of melange produced on Rakis, the Bene Tleilax tanks produced long tons". The technology "had broken the Rakian monopoly on the spice" but is not fully successful in pushing natural melange out of the marketplace.


Prequels and sequels


Project Amal

In the ''
Prelude to Dune The ''Dune'' prequel series is a sequence of novel trilogies written by Brian Herbert and Kevin J. Anderson. Set in the ''Dune'' universe created by Frank Herbert, the novels take place in various time periods before and in between Herbert's ...
''
prequel A prequel is a literary, dramatic or cinematic work whose story precedes that of a previous work, by focusing on events that occur before the original narrative. A prequel is a work that forms part of a backstory to the preceding work. The term " ...
trilogy A trilogy is a set of three works of art that are connected and can be seen either as a single work or as three individual works. They are commonly found in literature, film, and video games, and are less common in other art forms. Three-part wor ...
by
Brian Herbert Brian Patrick Herbert (born June 29, 1947) is an American author who lives in Washington (state), Washington state. He is the elder son of science fiction author Frank Herbert (who died in 1986). Brian Herbert's novels include ''Sidney's Comet' ...
and
Kevin J. Anderson Kevin James Anderson (born March 27, 1962) is an American science fiction author. He has written spin-off novels for ''Star Wars'', ''StarCraft'', ''Titan A.E.'' and ''The X-Files literature#Novels, The X-Files'', and with Brian Herbert is the ...
(1999–2001), Project Amal is an early attempt by the Bene Tleilax to create synthetic melange in order to eliminate dependence upon Arrakis. Upon presenting their idea to the
Padishah Emperor Multiple organizations of the ''Dune'' universe dominate the political, religious, and social arena of the setting of Frank Herbert's ''Dune'' series of science fiction novels, and derivative works. Set tens of thousands of years in the future, ...
Elrood Corrino IX ''Dune: House Atreides'' is a 1999 science fiction novel by Brian Herbert and Kevin J. Anderson, set in the fictional Dune (franchise), ''Dune'' universe created by Frank Herbert. It is the first book in the ''Prelude to Dune'' prequel trilogy, w ...
, in 10,154 A.G. the Tleilaxu are granted the right to occupy the planet Ix by force (with the help of Elrood's
Sardaukar Multiple organizations of the ''Dune'' universe dominate the political, religious, and social arena of the setting of Frank Herbert's ''Dune'' series of science fiction novels, and derivative works. Set tens of thousands of years in the future, ...
army) and remake it into a laboratory station for the project. The old Emperor wants to remove the spice monopoly by making sure that he has the only access to it, thus controlling the Spacing Guild. The Tleilaxu subsequently rename Ix "
Xuttuh The Bene Tleilax, also called Tleilaxu , are an extremely xenophobic and isolationist society in Frank Herbert's science fiction Dune (franchise), ''Dune'' universe. Genetics, Genetic manipulators who traffic in biological products such as artif ...
" after their founder. In the year 10,156 A.G., Elrood IX is assassinated by Count Hasimir Fenring at the behest of Crown Prince Shaddam. Shaddam, now under the name of Padishah Emperor Shaddam IV, gives Fenring the title of Imperial Spice Minister and orders him to supervise the project. Although Tleilaxu Master Hidar Fen Ajidica manages to create an artificial melange (called "ajidamal", or "amal") that seems to have the original's properties, it does not work properly. Test-
sandtrout A sandworm is a fictional Extraterrestrial life, extraterrestrial creature that appears in the Dune (franchise), ''Dune'' novels written by Frank Herbert, first introduced in ''Dune (novel), Dune'' (1965). Sandworms are colossal, worm-like cre ...
explode when exposed to it, and Fenring's test of its use by Guild Navigators ends in catastrophe as one
heighliner Technology is a key aspect of the fictional setting of the '' Dune series'' of science fiction novels written by Frank Herbert, and derivative works. Herbert's concepts and inventions have been analyzed and deconstructed in at least one book, ''T ...
and its passengers are destroyed and the Navigator of a second heighliner dies. When
Duke Leto Atreides The following is a list of secondary fictional characters from the science fiction media franchise '' Dune'' created by Frank Herbert. The characters listed originate in Herbert's novel series (1965–1985), but some also appear in the ''Prelude ...
invades Xuttuh in 10,175 A.G. and reestablishes Prince Rhombur of
House Vernius The ''Dune'' prequel series is a sequence of novel trilogy, trilogies written by Brian Herbert and Kevin J. Anderson. Set in the Dune (franchise), ''Dune'' universe created by Frank Herbert, the novels take place in various time periods before a ...
as ruler of Ix, all the records of Project Amal are destroyed by Fenring. When the news hits the
Landsraad Multiple organizations of the ''Dune'' universe dominate the political, religious, and social arena of the setting of Frank Herbert's Dune (franchise), ''Dune'' series of science fiction novels, and derivative works. Set tens of thousands of year ...
, Shaddam denies all participation, claiming never to have heard of it. He maintains that it had probably been something his senile father Elrood had done in his last days. The Tleilaxu Masters involved are ultimately executed. Ajidica himself dies from the side effects of ajidamal: his body literally falls apart as the synthetic melange had eaten it away from the inside out.


Ultraspice

In ''
Sandworms of Dune ''Sandworms of Dune'' is a science fiction novel by American writers Brian Herbert and Kevin J. Anderson, the second of two books they wrote to conclude Frank Herbert's original ''Dune'' series. It is based on notes left behind by Frank Herber ...
'', Brian Herbert and Anderson's 2007 conclusion to the original series, the Spacing Guild is manipulated into replacing its Navigators with Ixian navigation devices and cutting off the Navigators' supply of melange. Sure to die should they be without the spice, a group of Navigators commission Waff, an imperfectly awakened Tleilaxu ghola, to create "advanced" sandworms able to produce the melange they so desperately require. He accomplishes this by altering the DNA of the worm's sandtrout stage and creating an aquatic form of the worms, which are then released into the oceans of Buzzell. Adapting to their new environment, these "
seaworm A sandworm is a fictional extraterrestrial creature that appears in the ''Dune'' novels written by Frank Herbert, first introduced in ''Dune'' (1965). Sandworms are colossal, worm-like creatures that live on the desert planet Arrakis. The sa ...
s" quickly flourish, eventually producing a highly concentrated form of spice, dubbed ultraspice. This new form of spice is so powerful that a relatively small dose causes a potential
Kwisatz Haderach The Bene Gesserit () refers to a key social, religious, and political force in Frank Herbert's fictional ''Dune'' universe. The group is an exclusive sisterhood whose members train their bodies and minds through years of physical and mental ...
to descend into a complete and unbreakable coma through perfect prescience.


Analysis

In ''
Mycelium Running ''Mycelium Running: How Mushrooms Can Help Save the World'' is the sixth book written by American mycologist Paul Stamets. In ''Mycelium Running'' (Ten Speed Press 2005), Stamets explores the use and applications of fungi in bioremediation&mdash ...
'', mycologist
Paul Stamets Paul Edward Stamets (born July 17, 1955) is an American mycologist and entrepreneur who sells various mushroom products through his company. He is an author and advocate of medicinal fungi and mycoremediation. Early life Stamets was born in S ...
argues without sources that Herbert's creation of melange was related in part to his own personal experiences with
psilocybin mushroom Psilocybin mushrooms, commonly known as magic mushrooms, are a polyphyletic informal group of mushroom, fungi that contain psilocybin which turns into psilocin upon ingestion. Biological genera containing psilocybin mushrooms include ''Psilocyb ...
s. Carol Hart analyzes the concept of the drug in the essay "Melange" in ''
The Science of Dune BenBella Books is an independent publishing house based in Dallas, Texas. BenBella was founded by Glenn Yeffeth in 2001. It specializes in nonfiction books on popular culture, business, health, and nutrition, along with books on science, politics, ...
'' (2008). Also in ''Science of Dune'', Csilla Csori analyzes the concept of prescience in the essay "Prescience and Prophecy".


See also

*
Nootropic Nootropics ( , or ) (colloquial: smart drugs and cognitive enhancers, similar to adaptogens) are a wide range of natural or synthetic supplements or drugs and other substances that are claimed to improve cognitive function or to promote re ...
*
Synthetic cannabinoids Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. These novel psychoactive substances should not be confused with synthetic ...
* ''N'',''N''-Dimethyltryptamine


References and notes

{{DEFAULTSORT:Melange (Fictional Drug) Dune (franchise) Fictional medicines and drugs Smart drugs in fiction Fictional elements introduced in 1965