An ultrashort pulse laser is a

laser A laser is a device that emits light through a process of optical amplification based on the stimulated emission of electromagnetic radiation. The word "laser" is an acronym for "light amplification by stimulated emission of radiation". The fir ...

that emits

ultrashort pulse In optics, an ultrashort pulse, also known as an ultrafast event, is an electromagnetic pulse whose time duration is of the order of a picosecond (10−12 second) or less. Such pulses have a broadband optical spectrum, and can be created by ...

s of light, generally of the order of

femtosecond A femtosecond is a unit of time in the International System of Units (SI) equal to 10 or of a second; that is, one quadrillionth, or one millionth of one billionth, of a second. For context, a femtosecond is to a second as a second is to about 31. ...

s to one

picosecond A picosecond (abbreviated as ps) is a unit of time in the International System of Units (SI) equal to 10−12 or (one trillionth) of a second. That is one trillionth, or one millionth of one millionth of a second, or 0.000 000 000 ...

. They are also known as ultrafast lasers owing to the speed at which pulses "turn on" and "off"—not to be confused with the speed at which light propagates, which is determined by the properties of the medium (and has an

upper limit In mathematics, the limit inferior and limit superior of a sequence can be thought of as limiting (that is, eventual and extreme) bounds on the sequence. They can be thought of in a similar fashion for a function (see limit of a function). For a ...

), particularly its

index of refraction In optics, the refractive index (or refraction index) of an optical medium is a dimensionless number that gives the indication of the light bending ability of that medium. The refractive index determines how much the path of light is bent, or ...

, and can vary as a function of field intensity (i.e.

self-phase modulation Self-phase modulation (SPM) is a nonlinear optical effect of light–matter interaction. An ultrashort pulse of light, when travelling in a medium, will induce a varying refractive index of the medium due to the optical Kerr effect. This variation i ...

) and wavelength (

chromatic dispersion In optics, and by analogy other branches of physics dealing with wave propagation, dispersion is the phenomenon in which the phase velocity of a wave depends on its frequency; sometimes the term chromatic dispersion is used for specificity to ...

). Common current ultrashort pulse laser technologies include

Ti-sapphire laser Ti:sapphire lasers (also known as Ti:Al2O3 lasers, titanium-sapphire lasers, or Ti:sapphs) are tunable lasers which emit red and near-infrared light in the range from 650 to 1100 nanometers. These lasers are mainly used in scientific research beca ...

s and

dye laser A dye laser is a laser that uses an organic dye as the lasing medium, usually as a liquid solution. Compared to gases and most solid state lasing media, a dye can usually be used for a much wider range of wavelengths, often spanning 50 to 100 na ...

s. High output peak power usually requires

chirped pulse amplification Chirped pulse amplification (CPA) is a technique for amplifying an ultrashort laser pulse up to the petawatt level, with the laser pulse being stretched out temporally and spectrally, then amplified, and then compressed again. The stretching and c ...

of a seed pulse from a modelocked laser. Dealing with high optical powers also needs the

nonlinear optical Nonlinear optics (NLO) is the branch of optics that describes the behaviour of light in ''nonlinear media'', that is, media in which the polarization density P responds non-linearly to the electric field E of the light. The non-linearity is typic ...

phenomena to be taken in account.

Use in Pathogen Inactivation

Tsen and colleagues developed a

SEPHODIS Selective photonic disinfection (SEPHODIS) is an ultrashort pulse laser technology invented by Tsen and colleagues to combat pathogens including viruses and bacteria. SEPHODIS uses extremely brief pulses of light to destroy viral capsids while minim ...

(selective photonic disinfection) technology using an ultrashort pulse laser to kill viruses including

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

influenza virus ''Orthomyxoviridae'' (from Greek ὀρθός, ''orthós'' 'straight' + μύξα, ''mýxa'' 'mucus') is a family of negative-sense RNA viruses. It includes seven genera: ''Alphainfluenzavirus'', ''Betainfluenzavirus'', '' Gammainfluenzavirus'', ...

, and

norovirus Norovirus, sometimes referred to as the winter vomiting disease, is the most common cause of gastroenteritis. Infection is characterized by non-bloody diarrhea, vomiting, and stomach pain. Fever or headaches may also occur. Symptoms usually deve ...

es. The technique appears to damage viral capsids while preserving other proteins and biological materials, although these claims have been disputed elsewhere. The ultrashort pulse laser treatment may have potential applications in the disinfection of medicines, in the production of inactivated vaccines, and in the possible future treatment of blood-borne viral infections from agents such as

and

Ebola virus ''Zaire ebolavirus'', more commonly known as Ebola virus (; EBOV), is one of six known species within the genus ''Ebolavirus''. Four of the six known ebolaviruses, including EBOV, cause a severe and often fatal hemorrhagic fever in humans and ot ...

References

External links

* Ultrafast Lasers
An animated guide to the functioning of Ti:Sapphire lasers and amplifiers.
* Laser types {{Technology-stub

Use in Pathogen Inactivation

See also

References

External links