USS ''San Pablo'' may refer to:

Ships

* , a United States Navy ship in commission as a seaplane tender from 1943 to 1947 and as a hydrographic survey ship from 1948 to 1969

Literature and film

* USS ''San Pablo'', a fictional United States Navy gunboat that is the setting for the 1962 novel '' The Sand Pebbles'' and the 1966 movie ''The Sand Pebbles'' {{disambig