UR-AK49 is a drug used in scientific research which acts as a potent
antagonist for the
Neuropeptide Y
Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY has been identified as the most abundant peptide present in the ma ...
/
Pancreatic polypeptide
Pancreatic polypeptide (PP) is a polypeptide secreted by PP cells in the endocrine pancreas. It regulates pancreatic secretion activities, and also impacts liver glycogen storage and gastrointestinal secretion. Its secretion may be impacted by ...
receptor
Receptor may refer to:
* Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse
*Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a ...
Y4, and also as a
partial agonist
In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist. They may also be considered ligands which display both agonistic and antagonis ...
at the
histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Since histamine was discovered ...
receptors
H1 and
H2.
UR-AK49 is a pure antagonist at Y
4 with no partial agonist effects, and although it is only slightly selective for Y
4 over the related
Y1 and
Y5 receptors, as the first non-peptide Y
4 antagonist developed UR-AK49 is expected to be useful in the study of this receptor and its role in the body.
References
Histamine agonists
Imidazoles
Neuropeptide Y antagonists
Acylguanidines
Cyclohexyl compounds
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