The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for
histone
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn a ...
pre-mRNA processing.
The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the
histone
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn a ...
mRNA cleavage site.
The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone
pre-mRNA
A primary transcript is the single-stranded ribonucleic acid ( RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs. The primary transcripts designated to be mRNAs ...
processing.
See also
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Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a severe type of muscular dystrophy that primarily affects boys. Muscle weakness usually begins around the age of four, and worsens quickly. Muscle loss typically occurs first in the thighs and pelvis follow ...
*
Histone 3' UTR stem-loop
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn ar ...
*
LSM10
U7 snRNA-associated Sm-like protein LSm10 is a protein that in humans is encoded by the ''LSM10'' gene.
Interactions
LSM10 has been shown to interact
Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for ...
References
Further reading
External links
* {{Rfam, id=RF00066, name=U7 small nuclear RNA
The uRNA database
RNA splicing
Small nuclear RNA
Spliceosome