U12 Intron Database (U12DB) is a

biological database Biological databases are libraries of biological sciences, collected from scientific experiments, published literature, high-throughput experiment technology, and computational analysis. They contain information from research areas including genom ...

of containing the sequence of eukaryotic introns that are spliced out by a specialised

minor spliceosome The minor spliceosome is a ribonucleoprotein complex that catalyses the removal ( splicing) of an atypical class of spliceosomal introns (U12-type) from messenger RNAs in some clades of eukaryotes. This process is called noncanonical splicing, as op ...

that contains

U12 minor spliceosomal RNA U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/ U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U1 ...

in place of U2 spliceosomal RNA. These U12-dependent introns are under-represented in genome annotations because they often have non canonical splice sites. Release 1 of the database contains 6,397 known and predicted U12-dependent introns across 20 species.

References

External links

* https://genome.crg.cat/datasets/u12/ Biological databases Gene expression Spliceosome RNA splicing {{Biodatabase-stub