U.S. Route 122 may refer to:
*
U.S. Route 122 (1926–1934) in Delaware, Pennsylvania, and New Jersey, now part of U.S. Route 202
*
U.S. Route 122 (1935–1963)
U.S. Route 122 (US 122) was a United States Numbered Highway that was a spur of US 22. Located in the state of Pennsylvania, it existed from 1935 to 1963. At its greatest extent, the route ran from US 1 and Pennsylvania Route 472 (PA 472) in Oxfo ...
in Pennsylvania, now part of Pennsylvania Route 10 and Pennsylvania Route 61
{{road disambiguation
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