U-69,593 is a
drug which acts as a
potent and
selective κ1-opioid receptor agonist.
In animal studies it has been shown to produce
antinociception
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It i ...
,
,
anxiolysis
An anxiolytic (; also antipanic or antianxiety agent) is a medication or other intervention that reduces anxiety. This effect is in contrast to anxiogenic agents which increase anxiety. Anxiolytic medications are used for the treatment of anxiet ...
(at low doses),
,
and
diuresis
Diuresis () is increased urination (polyuria) or, in the related word senses more often intended, the physiological process that produces such an increase or the administration of medications to encourage that process. It involves extra urine pr ...
,
while having little effect on
gastrointestinal motility Gastrointestinal physiology is the branch of human physiology that addresses the physical function of the gastrointestinal (GI) tract. The function of the GI tract is to process ingested food by mechanical and chemical means, extract nutrients and ...
.
It also inhibits the
peripheral, though not
central secretion of
oxytocin and
vasopressin
Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP. It then trave ...
in rats.
See also
*
U-50,488
*The dichloro analog is called
spiradoline.
References
Acetamides
Opioids
Pyrrolidines
Kappa-opioid receptor agonists
Tetrahydrofurans
Spiro compounds
{{Analgesic-stub