The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess
Goldman-Hodgkin-Katz (open)
rectification.
These channels are regulated by several mechanisms including
signaling lipids,
oxygen tension
Blood gas tension refers to the partial pressure of gases in blood. There are several significant purposes for measuring gas tension. The most common gas tensions measured are oxygen tension (PxO2), carbon dioxide tension (PxCO2) and carbon monox ...
,
pH,
mechanical stretch, and
G-protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their act ...
s . Their name is derived from the fact that the α subunits consist of four
transmembrane
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways to permit the transport of specific substances across the membrane. They frequent ...
segments, and each pair of transmembrane segments contains a pore loop between the two transmembrane segments. Thus, each subunit has two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form
dimers in the membrane (whereas inward-rectifier α subunits form tetramers).
Each single channel does ''not'' have two pores; the name of the channel comes from the fact that ''each subunit'' has two P (pore) domains in its primary sequence.
To quote Rang and Dale (2015), "The nomenclature is
misleading, especially when they are incorrectly referred to as two-pore channels".
Below is a list of the 15 known two-pore-domain human
potassium channel
Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of c ...
s:
See also
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Ion channel
*
Potassium channel
Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of c ...
References
External links
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Ion channels