Trimethylsilylpropanoic acid
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Trimethylsilylpropanoic acid (TMSP or TSP) is a chemical compound containing a
trimethylsilyl A trimethylsilyl group (abbreviated TMS) is a functional group in organic chemistry. This group consists of three methyl groups bonded to a silicon atom minus;Si(CH3)3 which is in turn bonded to the rest of a molecule. This structural group is ch ...
group. It is used as internal reference in
nuclear magnetic resonance Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a strong constant magnetic field are perturbed by a weak oscillating magnetic field (in the near field) and respond by producing an electromagnetic signal with a ...
for aqueous solvents (e.g. D2O). For that use it is often deuterated (3-(trimethylsilyl)-2,2,3,3-tetradeuteropropionic acid or TMSP-''d''4). Other internal references that are frequently used in NMR experiments are DSS and tetramethylsilane.


References

Propionic acids Trimethylsilyl compounds Nuclear magnetic resonance {{NMR-stub