Testis-specific Y-encoded protein 1 is a
protein that in humans is encoded by the ''TSPY1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
The protein encoded by this gene is found only in testicular tissue and may be involved in
spermatogenesis
Spermatogenesis is the process by which haploid spermatozoa develop from germ cells in the seminiferous tubules of the testis. This process starts with the mitotic division of the stem cells located close to the basement membrane of the tubules ...
. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional
orthologous gene
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a spec ...
is found in
mice
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus'' ...
. Two transcript variants encoding different isoforms have been found for this gene. The protein is strongly overexpressed in
gonadoblastoma
A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells. Gonadoblastomas are by definition benign ...
.
See also
*
TSPYL1: TSPY1 like protein
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
{{protein-stub