Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human
gene encoding a protein of the same name.
Function
TRPs, mammalian homologs of the
Drosophila transient receptor potential
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), TRP ...
(trp) protein, are
ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ...
s that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a
kinase. As a channel, it conducts calcium and monovalent cations to
depolarize cells and increase intracellular calcium. As a kinase, it is capable of
phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular
ATP and by the kinase mutants.
upplied by OMIMref>
Interactions
TRPM7 has been shown to
interact with
PLCB1
1-Phosphatidylinositol-4,5-bisphosphate phospholipase beta-1 is an enzyme that in humans is encoded by the ''PLCB1'' gene.
Function
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol fro ...
and
PLCB2
1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the ''PLCB2'' gene.
Function
The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-tris ...
.
[
]
Clinical relevance
Defects in this gene have been associated to magnesium deficiency in human microvascular endothelial cells.
See also
* TRPM
TRPM is a family of transient receptor potential ion channels (''M'' standing for '' wikt:melastatin''). Functional TRPM channels are believed to form tetramers. The TRPM family consists of eight different channels, TRPM1–TRPM8.
Unlike the TRP ...
References
Further reading
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External links
*
Ion channels
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