Type II keratins (or Type II cytokeratins) constitutes the Type II
intermediate filaments
Intermediate filaments (IFs) are cytoskeletal structural components found in the cells of vertebrates, and many invertebrates. Homologues of the IF protein have been noted in an invertebrate, the cephalochordate '' Branchiostoma''.
Intermedi ...
(IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. The type 2 cytokeratins consist of basic or neutral, high molecular weight
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
s which in vivo are arranged in pairs of heterotypic Type I and Type II keratin chains, coexpressed during differentiation of simple and stratified epithelial tissues.
Type II cytokeratins are encoded on
chromosome 12
Chromosome 12 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 12 spans about 133 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the to ...
q and encompasses:
CK1,
CK2,
CK3,
CK4,
CK5
''CK5'' is a compilation album by Japanese contemporary R&B singer Crystal Kay, released on June 30, 2004. It commemorates the five years since her debut as a musician in 1999. On the same day, ''CK 99—04 Music Clips'', a video album compiling ...
,
CK6,
CK7 and
CK8. Their molecular weight ranges from 52 kDa (CK8) to 67 kDa (CK18).
See also
*
Type I keratin Type I keratins (or Type I cytokeratins) are cytokeratins that constitute the Type I intermediate filaments (IFs) of the intracytoplasmatic cytoskeleton, which is present in all mammalian epithelial cells. Most of the type I keratins consist of aci ...
External links
*
Proteopedia page on keratins
{{Fibrous proteins
Keratins