Type V collagen is a form of fibrillar

collagen Collagen () is the main structural protein in the extracellular matrix found in the body's various connective tissues. As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole ...

associated with classical Ehlers-Danlos syndrome. It is found within the

dermal/epidermal junction The dermoepidermal junction or dermal-epidermal junction (DEJ) is the area of tissue that joins the epidermal and the dermal layers of the skin. The basal cells in the stratum basale of the epidermis connect to the basement membrane by the anchori ...

, placental tissues, as well as in association with tissues containing

type I collagen Type I collagen is the most abundant collagen of the human body. It forms large, eosinophilic fibers known as collagen fibers. It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomys ...

. Autoimmunity against type V collagen is associated with lung transplant failure.

Genes

COL5A1 Collagen alpha-1(V) chain is a protein that in humans is encoded by the ''COL5A1'' gene. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or mo ...

COL5A2 Collagen alpha-2(V) chain is a protein that in humans is encoded by the ''COL5A2'' gene. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or mor ...

COL5A3 Collagen alpha-3(V) chain is a protein that in humans is encoded by the ''COL5A3'' gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' ...

References

External links

* Collagens {{protein-stub