Twenty Mile Creek or Twentymile Creek may refer to:
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Twenty Mile Creek (Georgia), a stream in Georgia
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Twentymile Creek (Lake Erie tributary), a stream in New York and Pennsylvania
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Twenty Mile Creek (Ontario)
The Twenty Mile Creek is a minor waterway, located in the Niagara Peninsula, Ontario, Canada. The creek is named for the location of its mouth, twenty miles (32 km) west of the Niagara River along the Lake Ontario shoreline. The Indigenous n ...
, a stream in Canada
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