Early life and education
Tsuneko Okazaki was born inWork leading to and discovery of Okazaki fragments
Tsuneko and Reiji Okazaki's early research consisted of studying DNA synthesis and specific nucleotide characteristics in frog eggs and sea urchins. This work led to the discovery of thymidine-diphosphate rhamnose, a sugar linked nucleotide, which then opened up the doors for them to work in the U.S. They worked at Washington University and Stanford University in the labs of J. L. Strominger and Arthur Kornberg, respectively, where there was a lot more availability of resources to further their research. Years later, after much research done in both the U.S and Japan, in 1968, Tsuneko and Reiji published their breakthrough findings on Okazaki fragments in ''PNAS''. After Reiji Okazaki's early death fromAdditional research contributions
Tsuneko has continued to be involved in different research projects up to this day, mainly investigating different aspects of DNA. She has served as head of laboratories, lead academic supervisor of students, and as a significant intellectual contributor. Specifically, her contributions have been on research done on revealing hGCMa as a placenta-specific transcription regulator, possibly involved in the expression of multiple placenta-specific genes. She contributed to research on the human centromere protein B found to induce translational positioning of nucleosomes on α-satellite sequences. She worked on understanding the genomic regulation of HLA-G and how the presence of a LINE1 gene silencer may explain the limited expression of HLA-G. She also contributed to the research on mice with characteristics of down syndrome in order to understand the genotype-phenotype characteristics of down syndrome in humans.Career involvements
Tsuneko was an associate professor in molecular biology at the School of Science in Nagoya University from 1967 to 1983. She held this position until she became a lead professor from 1983 to 1997. In 1997, she moved to the Institute of Comprehensive Medical Science, Fujita Health University, where she was a professor for five years and then became a visiting professor until 2008. Additionally, throughout the years of 2004 to 2007, her main job was in the Stockholm office, where she was the director of the Japan Society for the Promotion of Science. She was also CEO/president and director of Chromo Research Inc. from 2008 to 2015.Family life
In 1963, after coming back from conducting research at Washington and Stanford University along with her husband, Tsuneko had her first child. She then had her second child in 1973. Due to low nursery care in Japan at the time, Tsuneko had difficulty finding help to take care of her children, as she was working full-time with her research. She was part of a citizen's campaign where she marched for more availability of child-care support. /sup> Reiji Okazaki died in 1975, but Tsuneko continued working to complete the research they were working on.Recognitions
Tsuneko was awarded the L'Oréal-UNESCO Awards for Women in Science in 2000. She was also awarded the Medal with Purple Ribbon in 2000, the Order of the Sacred Treasure, ndGold Rays with Neck Ribbon in 2008. In 2015,External links
References
{{DEFAULTSORT:Okazaki, Tsuneko Japanese biologists 1933 births Living people People from Nagoya Academic staff of Nagoya University Nagoya University alumni L'Oréal-UNESCO Awards for Women in Science laureates 21st-century women scientists Persons of Cultural Merit Recipients of the Order of Culture Molecular biologists Women biologists Academic staff of Fujita Health University