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Trichloroethyl chloroformate is used in
2,2,2-Trichloroethoxycarbonyl (Troc) group is largely used as a
* 
* Deprotection using zinc metal
:
organic synthesis
Organic synthesis is a special branch of chemical synthesis and is concerned with the intentional construction of organic compounds. Organic molecules are often more complex than inorganic compounds, and their synthesis has developed into one o ...
for the introduction of the trichloroethyl chloroformate (Troc) protecting group
A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction. It plays an important role in multistep organic synthesis.
In many ...
for amines, thiols and alcohols
In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl () functional group bound to a saturated carbon atom. The term ''alcohol'' originally referred to the primary alcohol ethanol (ethyl alcohol), which is ...
. It readily cleaves vs other carbamates and can be used in an overall protecting group strategy.
The troc group is traditionally removed ''via'' Zn insertion in the presence of acetic acid, resulting in elimination and decarboxylation.
Amine protection – 2,2,2-Trichloroethoxycarbonyl (Troc)
:
2,2,2-Trichloroethoxycarbonyl (Troc) group is largely used as a protecting group
A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction. It plays an important role in multistep organic synthesis.
In many ...
for amines in organic synthesis
Organic synthesis is a special branch of chemical synthesis and is concerned with the intentional construction of organic compounds. Organic molecules are often more complex than inorganic compounds, and their synthesis has developed into one o ...
.
Most common amine protection methods
* 2,2,2-Trichloroethyl chloroformate, pyridine or aqueoussodium hydroxide
Sodium hydroxide, also known as lye and caustic soda, is an inorganic compound with the formula NaOH. It is a white solid ionic compound consisting of sodium cations and hydroxide anions .
Sodium hydroxide is a highly caustic base and alkali ...
at ambient temperature
:
* Electrolysis
In chemistry and manufacturing, electrolysis is a technique that uses direct electric current (DC) to drive an otherwise non-spontaneous chemical reaction. Electrolysis is commercially important as a stage in the separation of elements from n ...
:
* Deprotection using zinc metal
:
References
{{DEFAULTSORT:Trichlorethoxycarbonyl chloride, 2,2,2- Chloroformates Protecting groups Reagents for organic chemistry