The TrkB internal ribosome entry site (IRES) is an
RNA element which is present in the
5' UTR
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of ...
sequence of the mRNA.
TrkB
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the ''NTRK2'' gene. TrkB is a recepto ...
is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The
internal ribosome entry site An internal ribosome entry site, abbreviated IRES, is an RNA element that allows for translation initiation in a cap-independent manner, as part of the greater process of protein synthesis. In eukaryotic translation, initiation typically occurs at t ...
IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites.
See also
*
Mnt IRES
The Mnt internal ribosome entry site (Internal ribosome entry site, IRES) is an cis-regulatory element, RNA element. Mnt is a transcriptional repressor related to the Myc/Mad family of transcription factors. It is thought that this IRES allows eff ...
*
N-myc IRES
*
Tobamovirus IRES
References
External links
*
Cis-regulatory RNA elements
{{molecular-cell-biology-stub