Trimetrexate is a
quinazoline
Quinazoline is an organic compound with the formula C8H6N2. It is an aromatic heterocycle with a bicyclic structure consisting of two fused six-membered aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow crystalline solid ...
derivative. It is a
dihydrofolate reductase inhibitor
A dihydrofolate reductase inhibitor (DHFR inhibitor) is a molecule that inhibits the function of dihydrofolate reductase, and is a type of antifolate.
Since folate is needed by rapidly dividing cells to make thymine, this effect may be used to th ...
.
Uses
It has been used with
leucovorin
Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to tr ...
in treating
pneumocystis pneumonia.
It has been investigated for use in treating
leiomyosarcoma
Leiomyosarcoma is a malignant (cancerous) smooth muscle tumor. A benign tumor originating from the same tissue is termed leiomyoma. While leiomyosarcomas are not thought to arise from leiomyomas, some leiomyoma variants' classification is evolv ...
.
It is a
methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma.
[Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15;20(12):2876-80.]
References
External links
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Antifungals
Mammalian dihydrofolate reductase inhibitors
Protozoal dihydrofolate reductase inhibitors
Fungal dihydrofolate reductase inhibitors
Quinazolines
Antiprotozoal agents
Aromatic amines
Phenol ethers
Anilines
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