The enzyme Triacylglycerol lipase (also Triglyceride lipase, EC 3.1.1.3;systematic name triacylglycerol acylhydrolase) catalyses the hydrolysis of ester linkages of
triglycerides
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from ''tri-'' and ''glyceride'').
Triglycerides are the main constituents of body fat in humans and other vertebrates, as we ...
:
:
triacylglycerol
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids (from ''tri-'' and ''glyceride'').
Triglycerides are the main constituents of body fat in humans and other vertebrates, as ...
+ H
2O
diacylglycerol
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. DAGs can act as s ...
+ a
carboxylate
In organic chemistry, a carboxylate is the conjugate base of a carboxylic acid, (or ). It is an ion with negative charge.
Carboxylate salts are salts that have the general formula , where M is a metal and ''n'' is 1, 2,...; ''carboxylat ...
These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families.
Human proteins containing this domain
DAGLA;
DAGLB;
LOC221955
LOC, L.O.C., Loc, LoC, or locs may refer to:
Places
* Lóc, a village in Sângeorgiu de Pădure, Mureș County, Romania
* Lócs, a village in Vas county, Hungary
* Line of Contact, meeting place of Western and Eastern Allied forces at the e ...
;
The
pancreatic
The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e. it has both an endocr ...
enzyme acts only on an ester-water interface.
Nomenclature
Other names include ''lipase'', ''butyrinase'', ''tributyrinase'', ''Tween hydrolase'', ''steapsin'', ''triacetinase'', ''tributyrin esterase'', ''Tweenase'', ''amno N-AP'', ''Takedo 1969-4-9'', ''Meito MY 30'', ''Tweenesterase'', ''GA 56'', ''capalase L'', ''triglyceride hydrolase'', ''triolein hydrolase'', ''tween-hydrolyzing esterase'', ''amano CE'', ''cacordase'', ''triglyceridase'', ''triacylglycerol ester hydrolase'', ''amano P'', ''amano AP'', ''PPL'', ''glycerol-ester hydrolase'', ''GEH'', ''meito Sangyo OF lipase'', ''hepatic lipase'', ''lipazin'', ''post-heparin plasma protamine-resistant lipase'', ''salt-resistant post-heparin lipase'', ''heparin releasable hepatic lipase'', ''amano CES'', ''amano B'', ''tributyrase'', ''triglyceride lipase'', ''liver lipase'', ''hepatic monoacylglycerol acyltransferase'').
See also
*
Pancreatic lipase
Triglyceride lipases () are a family of lipolytic enzymes that hydrolyse ester linkages of triglycerides. Lipases are widely distributed in animals, plants and prokaryotes.
At least three tissue-specific isozymes exist in higher vertebrates, p ...
*
Gastric lipase
The stomach is a muscular, hollow organ in the gastrointestinal tract of humans and many other animals, including several invertebrates. The stomach has a dilated structure and functions as a vital organ in the digestive system. The stomach ...
*
Lingual lipase
Lingual lipase is a member of a family of digestive enzymes called triacylglycerol lipases, EC 3.1.1.3, that use the catalytic triad of aspartate, histidine, and serine to hydrolyze medium and long-chain triglycerides into partial glycerides an ...
References
External links
*
EC 3.1.1
Protein domains
Protein families
Peripheral membrane proteins
{{InterPro content, IPR002921